Francesco D’Andrea

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BACKGROUND Human adult adipose tissue is an abundant source of mesenchymal stem cells (MSCs). Moreover, it is an easily accessible site producing a considerable amount of stem cells. METHODOLOGY/PRINCIPAL FINDINGS In this study, we have selected and characterized stem cells within the stromal vascular fraction (SVF) of human adult adipose tissue with the(More)
A 5-bp deletion and a Val1000 polymorphism at the alpha(2)-macroglobulin (A2M) gene have recently been reported to be associated with late onset Alzheimer's disease (AD). As recently it has been suggested that the effect of the A2M gene on AD susceptibility may be limited to certain populations or families, we analyzed the segregation of A2M and(More)
We designed a randomized, placebo-controlled, multicentre trial involving 51 relapsing-remitting multiple sclerosis patients to determine the clinical efficacy of mitoxantrone treatment over 2 years. Patients were allocated either to the mitoxantrone group (27 patients receiving I.V. infusion of mitoxantrone every month for 1 year at the dosage of 8 mg/m2)(More)
Seven patients with spinal osteoid osteomas are reported and another 110 cases from the literature are reviewed. Among the patients spinal pain is the constant clinical complaint, while radicular pain and scoliosis are present in half of the patients. Whereas radiograms and tomograms of the spine are sometimes inadequate for diagnosis, bone scanning is(More)
Five patients with arachnoidal diverticula after lumbar operations are reported. Myelography was performed in all cases, spinal computed tomography scanning in three; three patients underwent surgical treatment with good clinical results. Arachnoidal diverticula are a rare complication of operations on the lumbar spine. Spinal computed tomography scanning(More)
Measurement of the optic nerve diameter by echographic technique has been performed in 40 patients with intracranial hypertension syndromes of various origin. In all the cases examined the diameter was always increased. Postoperative checks revealed a decrease of the nerve thickness until it reached the normal values. The changes in the optic nerve diameter(More)
In this study an interesting and not frequent case of non-traumatic chronic subdural haematoma after spinal anaesthesia is reported. After a careful review of the cases described in the literature, the Authors discussed the physiopathological mechanisms, emphasizing how the break of the bridge veins or of the subarachnoid granulations, the cerebral atrophy(More)
We present the results of a randomized double-blinded placebo controlled, multicenter trial, of low-dose mitoxantrone (MX), after one year, in 25 patients with relapsing-remitting multiple sclerosis, who had serial enhanced magnetic resonance imaging (MRI). Treatment groups were balanced for age, gender, duration of illness and neurological disability. Five(More)
BACKGROUND Lipomas are benign solid tumours that develop in soft tissues with origin in mesenchymal progenitors. Macroscopically, they appear as soft-elastic nodules, varying in volume from a few millimiters to several centimetres and can enlarge progressively. Although they are usually asymptomatic, they can cause symptoms due to nerve or vessel(More)
Ten cases of brain metastases with significant intracranial hemorrhage are examined. The most frequent primary tumors were melanoma and lung carcinoma; bleeding was more commonly intratumoral and intracerebral. The clinical onset was acute in 6 cases and gradual in 4; the average survival time was 2 months. Intracranial bleeding in patients with brain(More)