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The rise in antioxidant enzyme activity in the lungs of late-gestation fetuses is thought to be caused by the preparation of the pulmonary antioxidant system for birth. However, recent data have shown that such a rise also occurs in the livers of late-gestation fetuses. Consequently, this surge cannot solely be ascribed to the preparation of the pulmonary(More)
Although reactive oxygen species have been proposed to play a major role in the aging process, the exact molecular mechanisms remain elusive. In this study we investigate the effects of a perturbation in the ratio of Cu/Zn-superoxide dismutase activity (Sod1 dismutases .O2-to H2O2) to glutathione peroxidase activity (Gpx1 catalyses H2O2 conversion to H2O)(More)
During oxidative metabolism harmful reactive oxygen species (ROS) are generated. These species are neutralized by antioxidant enzymes. Firstly, superoxide dismutase (Sod) converts superoxide radicals (.O2-) to hydrogen peroxide (H2O2). Thereafter catalase (Cat) and glutathione peroxidase (Gpx) independently convert this to water. An imbalance in the ratio(More)
Oxidative metabolism produces a flux of superoxide anions that must be removed from the cellular environment if the cell is to survive. The levels of antioxidant enzyme involved in the elimination of superoxide anions and/or hydrogen peroxide were investigated in an attempt to correlate any changes in the levels of these enzymes during aging with changes in(More)
We investigate the complexity of the syntactic isomorphism problem of CNF Boolean Formulas (CSFI): given two CNF Boolean formulas ϕ(a 1 ,. .. , a n) and ϕ(b 1 ,. .. , b n) decide whether there exists a permutation of clauses, a permutation of literals and a bijection between their variables such that ϕ(a 1 ,. .. , a n) and ϕ(b 1 ,. .. , b n) become(More)
PURPOSE Discuss exhaustively the clinical aspects of hepatorenal syndrome (HRS), laboratory data, the progress made in understanding the pathogenesis, and treatment. DESIGN The work is a result of the research conducted in the framework of the most important studies on HRS. RESULTS AND CONCLUSIONS Functional renal failure (FRF) is the most severe(More)
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