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Modeling flow in an in vitro anatomical cerebrovascular model with experimental validation

In this study, a realistic in vitro experimental model and corresponding computational model of the cerebral vasculature are established that can be used to investigate flow and embolus migration and lodging in the brain and provide an in vitro benchmark data set for flow in a realistic cerebrovascular model.
PubMed (opens in a new tab)

Arterial pulsations drive oscillatory flow of CSF but not directional pumping

Simulations match the experimental results and show that arterial pulsations only drive oscillatory motion of CSF in the PVS, and the observed directional CSF flow can be explained by naturally occurring and/or experimenter-generated pressure differences.
Springer (opens in a new tab)

Functional hyperemia drives fluid exchange in the paravascular space

Simulations suggest that functional hyperemia may serve to increase metabolite clearance from the PVS, and show that the deformability of the brain tissue needs to be accounted for when studying fluid flow and metabolite transport.
Springer (opens in a new tab)

Gut-Brain Hydraulics: Brain motion and CSF circulation is driven by mechanical coupling with the abdomen

The brain is hydraulically linked to the abdominal compartment, and fluid flow in the brain is coupled to body movements, providing a mechanism by which the mechanics of the viscera directly impact brain health.
PubMed (opens in a new tab)
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