Francesco Costantino

Learn More
We tracked the results of 394 manual or automatic red blood cell exchanges done with a cell separator in 20 sickle cell patients at high risk for recurrent complications. Over an average of 6 years, none of the patients developed complications related to the procedure or to the increased blood use. It was safe and effective in preventing complications of(More)
BACKGROUND Ghrelin, a peptide mainly derived from the stomach, plays a pivotal role in the regulation of food intake, energy metabolism, and storage, as well as in insulin sensitivity. Ghrelin circulates in acylated (A-Ghr) and nonacylated (NA-Ghr) forms, and their potential differential associations with insulin resistance (IR) in childhood obesity remain(More)
To demonstrate that the 2-yr clinical follow-up of our patient strongly suggests that long-term therapy with posaconazole (POS) is safe and beneficial in treatment and prevention of relapses of, otherwise fatal, central nervous system mucormycosis. Mucormycosis is a very rare opportunistic mycotic infection of diabetic children. We present the 30-month(More)
We show that Kauffman brackets of colored framed graphs (also known as quantum spin networks) can be renormalized to a Laurent polynomial with integer coefficients by multiplying it by a coefficient which is a product of quantum factorials depending only on the abstract combinatorial structure of the graph. Then we compare the shadow-state sums and the(More)
A natural notion of complexity of a PL n-dimensional manifold is the minimal number of highest-dimensional simplices in a triangulation of the manifold. Such a complexity is an integer-valued function and is finite (for each k ≥ 0 there are only finitely many manifolds whose complexity is less than or equal to k). In order to find all the n-manifolds of(More)
Simulation games have been utilized as an educational tool in order to complement the traditional teaching methods. They have been widely applied in the teaching of different subjects such as business management, nursing, and medicine. This paper proposes a new simulation game which simulates a production system that consists of a set of machines,(More)
Invasive fungal infections are usually associated with immunocompromised states About 40-60% of these patients are refractory to standard antifungal therapy We describe the effect of posaconazole in the treatment of a 12 years-old girl with uncontrolled diabetes mellitus with life-threatening cerebral mucor mycosis and a 4 year old girl boy with chronic(More)
BACKGROUND A high frequency of blue eyes and fair skin are reported in northern European Caucasians with type 1 diabetes (T1D). Also there is an inverse relationship between latitude and T1D incidence. We determined whether iris colour and skin pigmentation are risk factors in a Caucasian population living in two Mediterranean regions located at the same(More)
OBJECTIVE To evaluate the celiac-associated humoral autoimmunity in child, adolescent, and adult patients at type 1 diabetes (DM1) onset and to determine whether DM1 celiac-specific humoral immunoreactivity occurs similarly to that in nondiabetic patients at celiac disease (CD) diagnosis. RESEARCH DESIGN AND METHODS IgA anti-transglutaminase autoantibody(More)