Francesco Costa

3Fabio Galbusera
3Angelo Ricchiuti
2Dario Gambaccini
2Santino Marchi
2Hans-Joachim Wilke
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Inflammatory bowel disease (IBD) and polyps, are common colorectal pathologies in western society and are risk factors for development of colorectal cancer (CRC). Genomic instability is a cancer hallmark and is connected to changes in chromosomal structure, often caused by double strand break formation (DSB), and aneuploidy. Cellular stress, may contribute(More)
BACKGROUND Sperm protein 17 (Sp17) is a highly conserved mammalian protein characterized in rabbit, mouse, monkey, baboon, macaque, human testis and spermatozoa. mRNA encoding Sp17 has been detected in a range of murine and human somatic tissues. It was also recognized in two myeloma cell lines and in neoplastic cells from patients with multiple myeloma and(More)
BACKGROUND CONTEXT There is no universal consensus regarding the biomechanical aspects and relevance on the primary stability of misplaced pedicle screws. PURPOSE The study is aimed to the determination of the correlation between axial pullout forces of pedicle screws with the possible screw misplacement, including mild and severe cortical violations. (More)
5HTTLPR polymorphism of serotonin transporter yields short (S) and long (L) alleles. SS and LS genotypes are associated with reduced expression of serotonin transporter. This cross-sectional study investigated the association of 5HTTLPR with symptom severity of irritable bowel syndrome (IBS). Patients with IBS (Rome III) and healthy controls were included.(More)
AIM To examine the links between quality of sleep and the severity of intestinal symptoms in irritable bowel syndrome (IBS). METHODS One hundred and forty-two outpatients (110 female, 32 male) who met the Rome III criteria for IBS with no psychiatric comorbidity were consecutively enrolled in this study. Data on age, body mass index (BMI), and a set of(More)
OBJECTIVE To assess the benefits and risks of short term (<12 months) or extended (>12 months) dual antiplatelet therapy (DAPT) versus standard 12 month therapy, following percutaneous coronary intervention with drug eluting stents. DESIGN Meta-analysis of randomised controlled trials. DATA SOURCES PubMed, Embase, Cumulative Index to Nursing and Allied(More)
BACKGROUND Pathological deformities involving the sagittal alignment of the spine may lead to loss of spine stability and imbalance. The effect of different patterns of sagittal balance on the loads acting in the spine was only marginally investigated, although it would be of critical importance in the clinical management of spinal disorders. METHODS(More)
The joint European Society of Cardiology and European Association of Cardio-Thoracic Surgery (ESC/EACTS) guidelines on myocardial revascularization collect and summarize the evidence regarding decision-making, diagnostics, and therapeutics in various clinical scenarios of coronary artery disease, including elective, urgent, and emergency settings. The 2014(More)
  • Donatella Talini, Federica Novelli, Elena Bacci, Marialaura Bartoli, Silvana Cianchetti, Francesco Costa +7 others
  • 2015
OBJECTIVE To evaluate the potential determinants of forced expiratory volume in 1 s (FEV1) decline in workers with occupational asthma (OA) still exposed to the causative agent. We hypothesised that sputum eosinophilia might be a predictor of poor asthma outcome after diagnosis. SETTING, DESIGN AND PARTICIPANTS In a specialistic clinical centre of the(More)
Bleeding is the most common adverse event after percutaneous coronary intervention (PCI). It can occur either as a direct complication of the index procedure or spontaneously during the antithrombotic treatment for secondary prevention. Hemorrhagic complications significantly impact the prognosis independently from their timing and have been associated with(More)