Francesco Agostini

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BACKGROUND Physical inactivity is often associated with positive energy balance and fat gain. OBJECTIVE We aimed to assess whether energy intake in excess of requirement activates systemic inflammation and antioxidant defenses and accelerates muscle atrophy induced by inactivity. DESIGN Nineteen healthy male volunteers were studied before and at the end(More)
PURPOSE OF REVIEW Glutamine is largely synthesized in skeletal muscles and provides fuel to rapidly dividing cells of the immune system and precursors to gluconeogenesis in the liver. Physical exercise is known to affect glutamine synthesis and to modulate glutamine uptake. Overtraining is frequently associated with reduced availability of glutamine and(More)
Oxidative stress is often associated to inactivity-mediated skeletal muscle atrophy. Glutathione is one of the major antioxidant systems stimulated, both at muscular and systemic level, by activation of oxidative processes. We measured changes in glutathione availability, oxidative stress induction and the extent of atrophy mediated by 35 days of(More)
BACKGROUND & AIMS Low-grade systemic inflammation and pro-inflammatory pattern of cell membrane fatty acid composition characterize patients affected by type 2 diabetes and metabolic syndrome. We hypothesize that inactivity-induced insulin resistance could affect levels of pro-inflammatory fatty acids in cell membranes. METHODS Thirty healthy, male, young(More)
BACKGROUND No effective therapy is available for hepatocellular carcinoma. To identify novel therapeutic strategies, we explored the effects of the depletion of E2F1, cyclin E1-E2 whose inter-relationships in hepatocellular carcinoma cell proliferation have never been defined. METHODS siRNA-mediated depletion of the targets was studied in the(More)
This article presents a review of the porous physical characteristics, phenomena and simulation models so far investigated and applied in the management of biodegradable wastes (BW), summarising the main properties of porous media and the dynamics of fluids within its voids. The aim is to highlight how the description of biodegradable wastes as porous media(More)
CONTEXT Physical inactivity is associated with insulin resistance and decreased high-density lipoprotein (HDL) cholesterol. Cholesteryl ester transfer protein (CETP) is involved in cholesterol metabolism, being responsible for the transfer of cholesteryl esters from HDL to very low- and low-density lipoproteins. OBJECTIVE We hypothesized that physical(More)
Glutamine synthesis and utilization are strictly linked to energy metabolism and physical activity. To investigate the interaction between bed rest and moderate energy restriction on whole body glutamine kinetics in healthy volunteers, we performed a four-period study in which each subject randomly underwent a bed rest or ambulatory 14 day period both in(More)
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