Francesca Porcellati

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OBJECTIVE Physical activity is a modifiable risk factor for type 2 diabetes, partly through its action on insulin sensitivity. We report the relation between insulin sensitivity and physical activity measured by accelerometry. RESEARCH DESIGN AND METHODS This is a cross-sectional study of 346 men and 455 women, aged 30-60 years, without cardiovascular(More)
OBJECTIVE Amino acids stimulate glucagon responses to hypoglycemia and may be utilized by the brain. The aim of this study was to assess the responses to hypoglycemia in nondiabetic and type 1 diabetic subjects after ingestion of an amino acid mixture. RESEARCH DESIGN AND METHODS Ten nondiabetic and 10 diabetic type 1 subjects were studied on three(More)
OBJECTIVE—Physical activity is a modifiable risk factor for type 2 diabetes, partly through its action on insulin sensitivity. We report the relation between insulin sensitivity and physical activity measured by accelerometry. RESEARCH DESIGN AND METHODS—This is a cross-sectional study of 346 men and 455 women, aged 30 – 60 years, without cardiovascular(More)
OBJECTIVE To investigate concentration of plasma insulin glargine after its subcutaneous dosing compared with concentration of its metabolites 1 (M1) and 2 (M2) in subjects with type 2 diabetes. RESEARCH DESIGN AND METHODS Nine subjects underwent a 32-h euglycemic glucose clamp study (0.4 units/kg glargine after 1 week of daily glargine administration).(More)
AIMS A multinational, randomized, double-blind, two-way crossover trial to compare the pharmacokinetic and pharmacodynamic properties of bolus, subcutaneously administered insulin glulisine (glulisine) and insulin aspart (aspart) in insulin-naÏve, obese subjects with type 2 diabetes. METHODS Thirty subjects [9/21 females/males; mean ± SD age: 60.7 ± 7.7(More)
on the day of the study. The last administration of OHA was the day before the study. At 12:00 h subjects were served a standardized meal (688 kcal, 54% carbohydrate, 30% protein, and 16% lipids) after a s.c. dose of lispro insulin rapid-acting insulin analogue (Humalog, Lilly and Co, Indianapolis, USA). At 15.30 h, subjects were placed in bed rest and(More)
OBJECTIVE Changes in glucose metabolism occurring during counterregulation are, in part, mediated by increased plasma free fatty acids (FFAs), as a result of hypoglycemia-activated lipolysis. However, it is not known whether FFA plays a role in the development of posthypoglycemic insulin resistance as well. RESEARCH DESIGN AND METHODS We conducted a(More)
M ore than 30 years ago in Diabetes Care, Schmidt et al. (1) defined " dawn phenomenon, " the night-to-morning elevation of blood glucose (BG) before and, to a larger extent, after breakfast in subjects with type 1 diabetes (T1D). Shortly after, a similar observation was made in type 2 diabetes (T2D) (2), and the physiology of glucose homeosta-sis at night(More)
T ype 2 diabetes over time associates with the development of vascular complications (1). The causative role of long-term elevation of blood glucose is well established, at least for microvascular complications, since intervention strategies directed at reducing hyperglycemia lower onset and/or progression of micro-angiopathy (1,2). The role of(More)