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MicroRNA 223-dependent expression of LMO2 regulates normal erythropoiesis
Erythropoiesis is tightly controlled by transcription factors, one of which is the LIM domain-only protein LMO2, but little is still known of the involvement of microRNAs (miRs) in erythroid cell… Expand
miR-126&126* Restored Expressions Play a Tumor Suppressor Role by Directly Regulating ADAM9 and MMP7 in Melanoma
The abnormal expression of several microRNAs has a causal role in tumorigenesis with either antineoplastic or oncogenic functions. Here we demonstrated that miR-126 and miR-126* play a tumor… Expand
Stem cell factor protects erythroid precursor cells from chemotherapeutic agents via up-regulation of BCL-2 family proteins.
Suppression of red blood cell production is a common complication of chemotherapy, causing anemia in a significant number of cancer patients. We have evaluated the sensitivity of human hematopoietic… Expand
SCD5‐induced oleic acid production reduces melanoma malignancy by intracellular retention of SPARC and cathepsin B
A proper balance between saturated and unsaturated fatty acids (FAs) is required for maintaining cell homeostasis. The increased demand of FAs to assemble the plasma membranes of continuously… Expand
IL-4 Protects Tumor Cells from Anti-CD95 and Chemotherapeutic Agents via Up-Regulation of Antiapoptotic Proteins1
- C. Conticello, F. Pedini, +6 authors R. de Maria
- Biology, Medicine
- The Journal of Immunology
- 1 May 2004
We recently proposed that Th1 and Th2 cytokines exert opposite effects on the pathogenesis and clinical outcome of organ-specific autoimmunity by altering the expression of genes involved in target… Expand
Multiple Members of the TNF Superfamily Contribute to IFN-γ-Mediated Inhibition of Erythropoiesis1
IFN-γ inhibits the growth and differentiation of erythroid precursor cells and mediates hemopoietic suppression through mechanisms that are not completely understood. We found that treatment of human… Expand
Absence of Caspase 8 and High Expression of PED Protect Primitive Neural Cells from Cell Death
- L. Ricci‐Vitiani, F. Pedini, +7 authors R. de Maria
- Medicine, Biology
- The Journal of experimental medicine
- 15 November 2004
The mechanisms that control neural stem and progenitor cell survival are unknown. In several pathological conditions, death receptor (DR) ligands and inflammatory cytokines exert a deleterious effect… Expand
Increased death receptor resistance and FLIPshort expression in polycythemia vera erythroid precursor cells.
Polycythemia vera (PV) is a clonal myeloproliferative disorder characterized by excessive erythrocyte production. Most patients with PV harbor an activating JAK2 mutation, but the molecular links… Expand
The Notch2–Jagged1 interaction mediates stem cell factor signaling in erythropoiesis
- A. Zeuner, F. Francescangeli, +6 authors R. Maria
- Biology, Medicine
- Cell Death and Differentiation
- 1 February 2011
Stem cell factor (SCF), the ligand for the c-kit receptor, is essential for the production of red blood cells during development and stress erythropoiesis. SCF promotes erythroblast proliferation and… Expand
Activity of the BH3 mimetic ABT-737 on polycythemia vera erythroid precursor cells.
An increased expression of antiapoptotic molecules is often found in malignant cells, where it contributes to their clonal expansion by conferring an improved survival ability. We found that… Expand