Francesca Mangiantini

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Mycophenolate mofetil (MMF) has proved to be an efficacious and safe therapy in adult lupus nephritis. Recently, this drug has been suggested as a possible new alternative treatment also for juvenile-onset SLE (juvenile-SLE). A multicenter study has been performed to evaluate the efficacy and safety of MMF in controlling the disease activity in children and(More)
IMPORTANCE Pediatric-onset Crohn disease is more aggressive than adult-onset disease, has high rates of resistance to existing drugs, and can lead to permanent impairments. Few trials have evaluated new drugs for refractory Crohn disease in children. OBJECTIVE To determine whether thalidomide is effective in inducing remission in refractory pediatric(More)
BACKGROUND In a randomized controlled trial, thalidomide has shown to be effective in refractory Crohn's disease in children. This pilot study aimed at evaluating thalidomide in refractory pediatric ulcerative colitis (UC). METHODS Double-blind, placebo-controlled randomized clinical trial on thalidomide 1.5 to 2.5 mg/kg/day in children with active UC(More)
Juvenile polyposis syndrome (JPS) is the most common of the hamartomatous syndromes and is characterised by the occurrence of multiple hamartomatous polyps affecting the gastrointestinal (GI) tract (1). As with the other hamartomatous syndromes described, there is an increased risk of colon cancer that arises from adenomaous components present in the(More)
The Authors present a case of a 11 year-old patient with a history of Juvenile Polyposis Syndrome (JPS), a condition characterized by the occurrence of multiple hamartomatous polyps in the gastrointestinal tract. Patients with JPS are traditionally treated by repeated endoscopic polypectomies and elective surgery. Recent studies reported up-regulation of(More)
resistance rates of Salmonella enterica strains isolated from children of two Southern European countries. The study included 9527 (2096 Italian and 7431 Spanish) children (median age: 3.0 years; range: 7 days to 19.2 years) admitted for acute diarrhoea to the Department of Paediatrics, University of Florence, Italy, and the Hospital Valle d’Hebron,(More)
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