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Hydroxytyrosol prevents metabolic impairment reducing hepatic inflammation and restoring duodenal integrity in a rat model of NAFLD.
TLDR
The data demonstrate the beneficial effect of HT in the prevention of early inflammatory events responsible for the onset of IR and steatosis, reducing hepatic inflammation and nitrosative/oxidative stress and restoring glucose homeostasis and intestinal barrier integrity. Expand
Polychlorinated biphenyls (PCB 101, PCB 153 and PCB 180) alter leptin signaling and lipid metabolism in differentiated 3T3-L1 adipocytes.
TLDR
The hypothesis that NDL-PCBs may interfere with the lipid metabolism contributing to the development of obesity and related diseases is strongly supported. Expand
Butyrate Regulates Liver Mitochondrial Function, Efficiency, and Dynamics in Insulin-Resistant Obese Mice
TLDR
Hepatic mitochondria were identified as the main target of the beneficial effect of both butyrate-based compounds in reverting insulin resistance and fat accumulation in diet-induced obese mice, and the shift of the mitochondrial dynamic toward fusion bybutyrate and FBA resulted in the improvement of mitochondrial cell energy metabolism but also of glucose homeostasis. Expand
Polyphenol‐rich virgin olive oil reduces insulin resistance and liver inflammation and improves mitochondrial dysfunction in high‐fat diet fed rats
TLDR
HPCOO limits HFD‐induced insulin resistance, inflammation, and hepatic oxidative stress, preventing nonalcoholic fatty liver disease progression, and reduces H2O2 release and aconitase activity by decreasing degree of coupling. Expand
Polychlorinated Biphenyls (PCB 101, 153, and 180) Impair Murine Macrophage Responsiveness to Lipopolysaccharide: Involvement of NF-κB Pathway
TLDR
NDL-PCBs reduce macrophage responsiveness, particularly when they are combined at concentrations per se inactive, impairing the capability to orchestrate a proper immune response to an infectious stimulus, disrupting TLR4/NF-κB pathway. Expand
Preventive and therapeutic effects of Lactobacillus paracasei B21060-based synbiotic treatment on gut inflammation and barrier integrity in colitic mice.
TLDR
The beneficial effects of this synbiotic formulation in acutely colitic mice are highlighted, suggesting that it may have therapeutic and possibly preventive efficacy in human colitis. Expand
N-(1-carbamoyl-2-phenylethyl) butyramide reduces antibiotic-induced intestinal injury, innate immune activation and modulates microbiota composition
TLDR
It is demonstrated that FBA has multiple converging mechanisms in limiting intestinal and hepatic alterations to counteract AIJ, and modulated key players of innate immunity in antibiotic-injured gut tissues, reducing inflammatory process and improving the anti-inflammatory and resolving pattern. Expand
Galactosylated Pro-Drug of Ursodeoxycholic Acid: Design, Synthesis, Characterization, and Pharmacological Effects in a Rat Model of Estrogen-Induced Cholestasis.
TLDR
UDCAgal, similarly to UDCA, heightens bile flow and modulates biliary acids secretion, and indicates that UDCAgal has a potential in the treatment of cholestatic disease. Expand
Palmitoylethanolamide Treatment Reduces Blood Pressure in Spontaneously Hypertensive Rats: Involvement of Cytochrome P450-Derived Eicosanoids and Renin Angiotensin System
TLDR
The mechanisms underpinning PEA blood pressure lowering effect are investigated, exploring the contribution of epoxyeicosatrienoic acids, CYP-dependent arachidonic acid metabolites, as endothelium-derived hyperpolarizing factors (EDHF), and renin angiotensin system (RAS) modulation. Expand
Palmitoylethanolamide counteracts hepatic metabolic inflexibility modulating mitochondrial function and efficiency in diet‐induced obese mice
TLDR
Findings identify PEA as a modulator of hepatic lipid and glucose homeostasis, limiting metabolic inflexibility induced by nutrient overload, as well as a pivotal role of AMPK in PEA‐induced adaptive metabolic setting. Expand