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7-Nitro-2,1,3-benzoxadiazole Derivatives, a New Class of Suicide Inhibitors for Glutathione S-Transferases
Spectroscopic and rapid kinetic experiments were performed to detail the interaction of human glutathione S-transferases GSTA1-1, GSTM2-2, and GSTP1-1 withExpand
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Proapoptotic activity of new glutathione S-transferase inhibitors.
Selected 7-nitro-2,1,3-benzoxadiazole derivatives have been recently found very efficient inhibitors of glutathione S-transferase (GST) P1-1, an enzyme which displays antiapoptotic activity and isExpand
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  • Open Access
Glutathione Transferases Sequester Toxic Dinitrosyl-Iron Complexes in Cells
It is now well established that exposure of cells and tissues to nitric oxide leads to the formation of a dinitrosyl-iron complex bound to intracellular proteins, but little is known about how theExpand
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GSTB1-1 from Proteus mirabilis
The native form of the bacterial glutathione transferase B1-1 (EC 2.5.1.18) is characterized by one glutathione (GSH) molecule covalently linked to Cys-10. This peculiar disulfide, only found in theExpand
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Glutathione Transferase Superfamily Behaves Like Storage Proteins for Dinitrosyl-Diglutathionyl-Iron Complex in Heterogeneous Systems*
Electron paramagnetic resonance and kinetics experiments have been made to determine the formation, stability, and fate of the natural nitric oxide carrier, dinitrosyl-diglutathionyl-iron complexExpand
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Binding and Kinetic Mechanisms of the Zeta Class Glutathione Transferase*
The Zeta class of glutathione transferases (GSTs) has only recently been discovered and hence has been poorly characterized. Here we investigate the substrate binding and kinetic mechanisms of theExpand
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Electrostatic Association of Glutathione Transferase to the Nuclear Membrane
The possible nuclear compartmentalization of glutathione S-transferase (GST) isoenzymes has been the subject of contradictory reports. The discovery that the dinitrosyl-diglutathionyl-iron complexExpand
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A Strong Glutathione S-Transferase Inhibitor Overcomes the P-glycoprotein-mediated Resistance in Tumor Cells
The new glutathione S-transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) is cytotoxic toward P-glycoprotein-overexpressing tumor cell lines, i.e. CEM-VBL10, CEM-VBL100,Expand
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Potent isozyme-selective inhibition of human glutathione S-transferase A1-1 by a novel glutathione S-conjugate
Summary.Elevated levels of glutathione S-transferases (GSTs) are among the factors associated with an increased resistance of tumors to a variety of antineoplastic drugs. Hence a major advancement toExpand
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Cooperativity and Pseudo-cooperativity in the Glutathione S-Transferase from Plasmodium falciparum*
Binding and catalytic properties of glutathione S-transferase from Plasmodium falciparum (PfGST) have been studied by means of fluorescence, steady state and pre-steady state kinetic experiments, andExpand
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