Francesca D'autilia

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The management of difficult to heal wounds can considerably reduce the time required for tissue repairing and promote the healing process, minimizing the risk of infection. Silver compounds, especially silver sulfadiazine (AgSD), are often used to prevent or to treat wound colonization, also in presence of antibiotic-resistant bacteria. However, AgSD has(More)
Nanocapsules and nanoparticles play an essential role in the delivery of pharmaceutical agents in modern era, since they can be delivered in specific tissues and cells. Natural polymers, such as cellulose acetate, are becoming very important due to their availability, biocompatibility, absence of toxicity and biodegradability. In parallel, essential oils(More)
Liquid-liquid interfaces are highly dynamic and characterized by an elevated interfacial tension as compared to solid-liquid interfaces. Therefore, they are gaining an increasing interest as viable templates for ordered assembly of molecules and nanoparticles. However, liquid-liquid interfaces are more difficult to handle compared to solid-liquid(More)
Here we provide demonstration that image mean square displacement (iMSD) analysis is a fast and robust platform to address living matter dynamic organization at the level of sub-cellular nanostructures (e.g. endocytic vesicles, early/late endosomes, lysosomes), with no a-priori knowledge of the system, and no need to extract single trajectories. From each(More)
1 Nanoscopy, Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genova, Italy 2 Dept. Of Physics, University of Genoa, Via Dodecaneso 33, 16146, Genova, Italy 3 Nikon Imaging Center @IIT, Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genova, Italy 4 NEST, Scuola Normale Superiore and Istituto Nanoscienze CNR, Piazza San Silvestro 12, I-56127(More)
Cell-sized polyelectrolyte capsules functionalized with a redox-driven proton pump protein were assembled for the first time. The interaction of polyelectrolyte microcapsules, fabricated by electrostatic layer-by-layer assembly, with cytochrome c oxidase molecules was investigated. We found that the cytochrome c oxidase retained its functionality, that the(More)
Second Harmonic Generation (SHG) microscopy exploits a second order nonlinear coherent optical process to image macromolecules with non-centrosymmetric structure, like collagen fibers [1]. Such a label-free approach can provide three-dimensional (3D) imaging of the structural organization and orientation of non-centrosymmetric molecules in different kind of(More)
By a combination of UV-Vis analyses, NMR-based diffusion measurements and MD simulations we have demonstrated for the first time that the HIV-1 Tat arginine-rich peptide (Tat11) is able to self-aggregate in both its fluorescently labeled and unlabeled variants. We propose Tat11 dimerization as the dominant aggregation process and show that the associated(More)
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