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BACKGROUND Monoclonal B cell lymphocytosis (MBL) is a preclinical condition characterized by an expansion of clonal B cells in the absence of B lymphocytosis (BALC < 5 × 10(9)/L) in the peripheral… Continue Reading
Multiple myeloma (MM) is a disease characterized by clonal proliferation of plasma cells with a complex genomic phenotype. We recently demonstrated that MM cells have signs of ongoing DNA damage and… Continue Reading
Multiple myeloma (MM) is a clonal proliferation of malignant plasma cells, carrying abnormal karyotypes, chromosomal translocations, and innumerous DNA copy-number variations. We and others have… Continue Reading
Introduction: For fit multiple myeloma (MM) patients, autologous hematopoietic stem cell transplant (HSCT) is standard of care as part of first line therapy, demonstrating longer progression-free… Continue Reading
Background: Multiple myeloma (MM) cells show a variable combination of chromosomal translocations, copy-number variations, somatic mutations and clonal heterogeneity, which makes every patient… Continue Reading