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and a new head grows back where a head should be and a new tail grows back where a tail should be. So, what decides whether it’s heads or tails? Two reports now answer this century-old question. They(More)
(SAC) blocks chromosome segregation until all sister chromatids are properly attached to the mitotic spindle. It does so by inactivating CDC20 (also known as Slp1 and Fizzy) — an essential activator(More)
embryology, an early mouse embryo is composed of two cell layers: the epiblast (ectoderm) and the visceral endoderm, which covers the epiblast. During gastrulation, the epiblast generates two other(More)
...all nonLys63-linked polyubiquitin chains mediate proteasomal degradation... Ubiquitin has seven Lys residues, which all contribute to the assembly of polyubiquitin chains on protein substrates.(More)