Francesca Bruno

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BACKGROUND Branchio-oto-renal (BOR) syndrome is an autosomal dominant disorder characterized by branchial, ear, and renal anomalies. The most common gene mutated in BOR patients is EYA1, the human homolog of the Drosophila eyes absent gene, while mutations in SIX1 gene, the human homolog of sine oculis, encoding a DNA binding protein interacting with EYA1,(More)
BACKGROUND Autosomal dominant polycystic kidney disease (ADPKD) is the most common form of cystic kidney disease. An inappropriate stimulation of mammalian target of rapamycin may represent the converging point in the molecular pathways leading to renal cyst growth. METHODS The primary objectives of this prospective, open-label, randomized clinical trial(More)
Pentraxin-3 (PTX3) is a member of the pentraxin family of innate immune regulators, which includes C-reactive protein (CRP). PTX3 has been implicated in angiogenesis, proliferation, and immune escape in cancer. In the present study, we evaluated PTX3 tissue expression and serum concentration as a biomarker to discriminate prostatic inflammation and benign(More)
In solid-organ transplant recipients (SOTR) the protective role of human cytomegalovirus (HCMV)-specific CD4+, CD8+ and γδ T-cells vs. HCMV reactivation requires better definition. The aim of this study was to investigate the relevant role of HCMV-specific CD4+, CD8+ and γδ T-cells in different clinical presentations during the post-transplant period.(More)
The past two decades have witnessed an increasing interest in the use of space-time models for a wide range of environmental problems. The fundamental tool used to embody both the temporal and spatial components of the phenomenon in question is the covariance model. The empirical estimation of space-time covariance models can prove highly complex if(More)
OBJECTIVE To determine the contributions of body mass, adiposity, and muscularity to physical function and muscle strength in adult patients with Bethlem myopathy (BM) and Ullrich congenital muscular dystrophy (UCMD). MATERIALS AND METHODS Evaluation involved one UCMD and 7 BM patients. Body composition was determined by body mass index (BMI) and(More)
In the last two decades space-time models have been studied with increasing interest. The main reason for these developments is their importance to problems of spatio-temporal prediction for environmental processes. The space-time covariance model is the fundamental tool for characterizing both the temporal and spatial components of the phenomena under(More)
Pr ecis: This study suggests a route through which senescence can be defeated to blunt a fail-safe mechanism that can restrain the powerful oncogenic effects of deregulated MYC, which underpins the malignant development of most human tumors. Pr ecis: These findings encourage further evaluation of an innate immune regulator as a noninvasive biomarker that(More)
Following primary human cytomegalovirus (HCMV) infection, both humoral and T-cell-mediated immune responses develop in immunocompetent subjects. However, while antibodies may be measured by different methodologies, the T-cell-mediated response remains to be analyzed in its polyfunctional aspects, in view of defining (following different stimuli) the optimal(More)
The economic convergence among European regions over the period 1980-2006 is analysed in the first place by using a conditional β-convergence model and a distance-based weight matrix and secondarily by a spatially-conditioned stochastic kernel approach. A Spatial Autoregressive model which identifies two spatial regimes and spatial dependence finds that the(More)