Frances Sharpe

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An enzymatic preparation from human brain converts tryptamine to tryptoline (9H-1,2,3,4-tetrahydropyrido(3,4-b)indole) in the presence of 5-methyltetrahydrofolic acid. Similarly, N-methyltryptamine and 5-hydroxytryptamine yield 1-methyltryptoline and 5-hydroxytryptoline, respectively. Neither in vitro nor in vivo formation of these compounds by human(More)
One thousand consecutive closed diaphyseal tibial fractures, treated with prefabricated functional below-knee braces, were analyzed by statistical methods to determine factors predictive of final fracture outcome. Neither the age of the patient nor the location of the fracture influenced the speed of healing. In 95% of the fractures, the final shortening(More)
Healing of 0.5 or 1.0-millimeter step-off defects associated with displaced intra-articular fractures of the medial femoral condyle was examined in fifty-four adult New Zealand White rabbits. The rabbits were treated with either immobilization for three weeks, intermittent active motion, or continuous passive motion for seven days. At twelve weeks, the(More)
Sixteen consecutive patients who were treated with a pedicled latissimus dorsi flap for complex soft tissue defects about the elbow were reviewed. The average defect size was 100 cm2. Thirteen of the 16 patients achieved stable wound healing with a single procedure. Three patients had partial necrosis of the latissimus and required additional coverage(More)
As with many diagnoses in medicine, the best treatment for Volkmann's ischemic contracture is prevention. Early recognition and prompt treatment of impending Volkmann's ischemia should decrease the presentation and severity of late contracture and hand dysfunction. The authors have found the flexor muscle slide the best treatment option for mild and(More)
The treatment of soft tissue problems about the elbow should be directed toward early coverage and functional rehabilitation. The current study reviews some of the available treatment options, with emphasis on the treatment of large soft tissue defects. The role of prophylactic soft tissue coverage also is discussed. For large defects not extending more(More)
In summary, the authors believe that traumatic bone defects of the diaphyseal forearm, fewer than 6 cm in length, can be well managed with corticocancellous bone grafting, provided the patient has an adequate soft-tissue envelope. In cases of soft-tissue compromise, primary bone grafting is still the treatment of choice, combined with simultaneous(More)
BACKGROUND Functional losses in the upper extremity that cannot be restored by nerve or tendon transfer present a treatment dilemma to the reconstructive surgeon. Common indications for functional free muscle transfer include late reconstruction of brachial plexus injuries, traumatic muscle loss, Volkmann ischemic contracture, loss resulting from oncologic(More)
The title of “The Relationship Between Catastrophic Thinking andHandDiagramAreas” catches the reader’s eye because it seems to support the clinical experience we havewith the patient with a “wandering finger,”who, when asked to localize the area of pain, has a finger that meanders the course of the entire limb. However, it was surprising that the role of(More)