Frances S. Silverman

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Exposure to air pollution has been shown to cause arterial vasoconstriction and alter autonomic balance. Because these biologic responses may influence systemic hemodynamics, we investigated the effect of air pollution on blood pressure (BP). Responses during 2-hr exposures to concentrated ambient fine particles (particulate matter < 2.5 microm in(More)
BACKGROUND Fine particulate air pollution and ozone are associated with increased cardiovascular events. To help explain the mechanism behind these observations, we investigated the effect of air pollution exposure on vascular function. METHODS AND RESULTS Twenty-five healthy adults underwent a randomized, double-blind, crossover study comparing the(More)
BACKGROUND Human controlled-exposure studies have assessed the impact of ambient fine particulate matter on cardiac autonomic function measured by heart rate variability (HRV), but whether these effects are modified by concomitant ozone exposure remains unknown. OBJECTIVE In this study we assessed the impact of O(3) and particulate matter exposure on HRV(More)
The relation between inhalation of ambient concentrations of ozone and airway reactivity to inhaled allergens may be important in asthma, since both agents can produce inflammatory changes in the airways. Seven asthmatic patients (mean age 40 [SD 13] years), with seasonal symptoms of asthma and positive skin tests for ragweed or grass, took part in a study(More)
BACKGROUND Short-term exposures to fine (<2.5 μm aerodynamic diameter) ambient particulate-matter (PM) have been related with increased blood pressure (BP) in controlled-human exposure and community-based studies. However, whether coarse (2.5 to 10 μm) PM exposure increases BP is uncertain. Recent observational studies have linked PM exposures with blood(More)
INTRODUCTION Systemic inflammation may be one of the mechanisms mediating the association between ambient air pollution and cardiovascular morbidity and mortality. Interleukin-6 (IL-6) and fibrinogen are biomarkers of systemic inflammation that are independent risk factors for cardio-vascular disease. OBJECTIVE We investigated the association between(More)
  • Daniel Johannes Mashao, Dean Harvey, F Silverman, P David, Morgan, Mike Wazlowski +7 others
  • 1996
Atteridgeville, west of Pretoria and only about 10 kilometers from the center of the town. Daniel completed matric (grade 12) in 1982. Without any nancial aid and money to aaord college he went to the University of Cape Town (UCT) for a science degree in Engineering. His application for permission to study at the then whites only university was granted by(More)
BACKGROUND Arginase overexpression contributes to airways hyperresponsiveness (AHR) in asthma. Arginase expression is further augmented in cigarette smoking asthmatics, suggesting that it may be upregulated by environmental pollution. Thus, we hypothesize that arginase contributes to the exacerbation of respiratory symptoms following exposure to air(More)
BACKGROUND The environment is suspected to play an important role in the development of childhood asthma. Cohort studies are a powerful observational design for studying exposure-response relationships, but their power depends in part upon the accuracy of the exposure assessment. OBJECTIVE The purpose of this paper is to summarize and discuss issues that(More)