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Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells
TLDR
It is demonstrated that expression of GARP on activated Tregs correlates with their suppressive capacity, and GARP expression correlates with FOXP3-expressing T cells in human immunodeficiency virus (HIV) −infected subjects. Expand
Expression and Function of TNF and IL-1 Receptors on Human Regulatory T Cells
TLDR
The findings that human Tregs preferentially express receptors for TNF and IL-1 suggest a potential function in sensing and dampening local inflammation. Expand
Trichomonas vaginalis homolog of macrophage migration inhibitory factor induces prostate cell growth, invasiveness, and inflammatory responses
TLDR
It is shown that chronic T. vaginalis infections may result in TvMIF-driven inflammation and cell proliferation, thus triggering pathways that contribute to the promotion and progression of prostate cancer. Expand
Trichomonas vaginalis: Pathogenesis, Symbiont Interactions, and Host Cell Immune Responses.
TLDR
Recent Tv research has uncovered new players that contribute to multifactorial mechanisms of host-parasite adherence and killing, and has examined the relationship between Tv and vaginal bacteria. Expand
The Metalloprotease ADAM12 Regulates the Effector Function of Human Th17 Cells
TLDR
A novel regulatory role for ADAM12 is revealed in Th17 cell differentiation or function and may have implications in regulating their aberrant responses during immune pathologies. Expand
Leukocyte Lysis and Cytokine Induction by the Human Sexually Transmitted Parasite Trichomonas vaginalis
TLDR
In vitro, it is determined that in vitro, Tv is able to lyse T-cells and B-cells, showing a preference for B- cells, and that Tv lysis of lymphocytes was mediated by contact-dependent and soluble factors, while a common symbiont of Tv, Mycoplasma hominis, had a major impact on cytokine responses. Expand
Differentiation of IL-17–Producing Effector and Regulatory Human T Cells from Lineage-Committed Naive Precursors
TLDR
It is shown that IL-17–producing T cells can differentiate from CCR6+ naive T cell precursors in the presence of IL-2, IL-1β, TGF-β, and IL-23, and the IL- 17+ Treg compartment was preferentially reduced relative to the canonical Th17 and Treg compartments in a subset of HIV+ subjects, suggesting a specific perturbation of this subset during the course of disease. Expand
The biology of FoxP3: a key player in immune suppression during infections, autoimmune diseases and cancer.
TLDR
The finding that FoxP3 is required for the development and function of Tregs has led to an explosion of research in determining its regulation and function in the immune system. Expand
Neutrophils kill the parasite Trichomonas vaginalis using trogocytosis
TLDR
These analyses provide the first demonstration, to the authors' knowledge, of a mammalian phagocyte using trogocytosis for pathogen clearance and reveal a novel mechanism used by PMNs to kill a large, highly motile target. Expand
Probing the Effector and Suppressive Functions of Human T Cell Subsets Using Antigen-Specific Engineered T Cell Receptors
TLDR
The engineered-TCR system reported here advances the ability to understand the differentiation pathways of naïve T cells into antigen-specific effector cells and the role of antigen- specific signaling in Treg-mediated immune suppression. Expand
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