Frances Ka-Yin Lin

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The gene for mouse erythropoietin was cloned and sequenced. We present here a preliminary analysis of the overall genomic organization of the coding portions and the two flanking regions of the gene. This is the third mammalian erythropoietin for which the sequence is available, but it represents the first from a nonprimate species. We investigated the(More)
Reprogramming of cancer cells into induced pluripotent stem cells (iPSCs) opens up the possibility of converting malignant cells into any cell type, including those best suited to be developed as cancer vaccines. Mouse models are needed to evaluate and optimize the therapeutic efficacy of such novel cancer vaccines. However, only human cancer cell lines(More)
The RNA of the mycelium ofRhizoctonia solani was studied in cells of three different ages. Components corresponding to 25S and 18S, rRNA, and 4S+5S RNA were present in approximately the same ratios in cells of each age. The rates of synthesis of all RNA species were markedly reduced in the cells of the older mycelium, though turnover rates were not(More)
Brain and Reproductive Organ Expressed (BRE), or BRCC45, is a death receptor-associated antiapoptotic protein, which is also involved in DNA-damage repair, and K63-specific deubiquitination. BRE overexpression attenuates both death receptor- and stress-induced apoptosis, promotes experimental tumor growth, and is associated with human hepatocellular and(More)
Lactogenesis in mammary gland of the mouse requires cortisol (or corticosterone) and prolactin. In this paper we review some recent findings in our laboratory regarding influence of the corticosteroid on casein mRNA activity of lactating mammary gland. Adrenal ablation in nursing mothers results in loss of larger ribosomal aggregates (polysomes) from(More)
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