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- David Allan Drummond, Jesse D. Bloom, Christoph Adami, Claus O. Wilke, Frances H. Arnold
- Proceedings of the National Academy of Sciences…
- 2005
Much recent work has explored molecular and population-genetic constraints on the rate of protein sequence evolution. The best predictor of evolutionary rate is expression level, for reasons that… (More)
- Todd Thorsen, Richard W Roberts, Frances H. Arnold, Stephen R Quake
- Physical review letters
- 2001
Spatiotemporal pattern formation occurs in a variety of nonequilibrium physical and chemical systems. Here we show that a microfluidic device designed to produce reverse micelles can generate… (More)
- Jesse D. Bloom, Sy T Labthavikul, Christopher R. Otey, Frances H. Arnold
- Proceedings of the National Academy of Sciences…
- 2006
The biophysical properties that enable proteins to so readily evolve to perform diverse biochemical tasks are largely unknown. Here, we show that a protein's capacity to evolve is enhanced by the… (More)
- Christopher A. Voigt, Carlos Sainz Martinez, Zhen-Gang Wang, Stephen L. Mayo, Frances H. Arnold
- Nature Structural Biology
- 2002
Borrowing concepts from the schema theory of genetic algorithms, we have developed a computational algorithm to identify the fragments of proteins, or schemas, that can be recombined without… (More)
Pattern formation is a hallmark of coordinated cell behaviour in both single and multicellular organisms. It typically involves cell–cell communication and intracellular signal processing. Here we… (More)
- Huimin Zhao, Lori Giver, Zhixin Shao, Joseph A. Affholter, Frances H. Arnold
- Nature Biotechnology
- 1998
We have developed a simple and efficient method for in vitro mutagenesis and recombination of polynu-cleotide sequences. The staggered extension process (StEP) consists of priming the template… (More)
- Jesse D. Bloom, Jonathan J Silberg, Claus O. Wilke, David Allan Drummond, Christoph Adami, Frances H. Arnold
- Proceedings of the National Academy of Sciences…
- 2005
We present a simple theory that uses thermodynamic parameters to predict the probability that a protein retains the wild-type structure after one or more random amino acid substitutions. Our theory… (More)
- Sabine Bastian, Xiang ming Liu, Joseph T. Meyerowitz, Christopher D. Snow, Mike Yen-Yang Chen, Frances H. Arnold
- Metabolic engineering
- 2011
2-methylpropan-1-ol (isobutanol) is a leading candidate biofuel for the replacement or supplementation of current fossil fuels. Recent work has demonstrated glucose to isobutanol conversion through a… (More)
- Katie Brenner, Lingchong You, Frances H. Arnold
- Trends in biotechnology
- 2008
Microbial consortia are ubiquitous in nature and are implicated in processes of great importance to humans, from environmental remediation and wastewater treatment to assistance in food digestion.… (More)
- L P Giver, Alexander Gershenson, P O Freskgård, Frances H. Arnold
- Proceedings of the National Academy of Sciences…
- 1998
We have used in vitro evolution to probe the relationship between stability and activity in a mesophilic esterase. Previous studies of these properties in homologous enzymes evolved for function at… (More)