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- Publications
- Influence
Libraries of hybrid proteins from distantly related sequences
- V. Sieber, C. Martinez, Frances H. Arnold
- Biology, Medicine
- Nature Biotechnology
- 1 May 2001
We introduce a method for sequence homology–independent protein recombination (SHIPREC) that can create libraries of single-crossover hybrids of unrelated or distantly related proteins. The method… Expand
Laboratory evolution of cytochrome P450 BM‐3 monooxygenase for organic cosolvents
- Tuck Seng Wong, Frances H. Arnold, U. Schwaneberg
- Chemistry, Medicine
- Biotechnology and bioengineering
- 5 February 2004
Cytochrome P450 BM‐3 (EC 1.14.14.1) catalyzes the hydroxylation and/or epoxidation of a broad range of substrates, including alkanes, alkenes, alcohols, fatty acids, amides, polyaromatic… Expand
Combinatorial Alanine Substitution Enables Rapid Optimization of Cytochrome P450BM3 for Selective Hydroxylation of Large Substrates
- Jared C. Lewis, Simone M. Mantovani, +4 authors Frances H. Arnold
- Chemistry, Medicine
- Chembiochem : a European journal of chemical…
- 10 December 2010
Made for each other: Combinatorial alanine substitution of active site residues in a thermostable cytochrome P450_(BM3) variant was used to generate an enzyme that is active with large substrates.… Expand