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Crystal structure of p50/p65 heterodimer of transcription factor NF-κB bound to DNA

• Frances E. Chen, D Huang, Yong-qing Chen, Gourisankar Ghosh
• Nature
• 1998

The NF-κB p50/p65 heterodimer is the classical member of the Relfamily of transcription factors which regulate diverse cellular functions such as immune response, cell growth, and development. Other… (More)

Regulation of DNA binding by Rel/NF-kappaB transcription factors: structural views.

• Frances E. Chen, Gourisankar Ghosh
• Oncogene
• 1999

Rel/NF-kappaB transcription factors form homo- and heterodimers with different DNA binding site specificities and DNA binding affinities. Several intracellular pathways evoked by a wide range of… (More)

Differential transcriptional regulation of individual TCR V beta segments before gene rearrangement.

• Frances E. Chen, Lee Rowen, Leroy Hood, Ellen V Rothenberg
• Journal of immunology
• 2001

The promoter sequences of individual murine TCR Vbeta segments are dissimilar, but any functional differences between them are masked after productive gene rearrangement by the dominance of the… (More)

Regulation of DNA binding by Rel/NF-κB transcription factors: structural views

• Frances E. Chen, Gourisankar Ghosh
• Oncogene
• 1999

Rel/NF-κB transcription factors form homo- and heterodimers with different DNA binding site specificities and DNA binding affinities. Several intracellular pathways evoked by a wide range of… (More)

Construction, expression, purification and functional analysis of recombinant NFkappaB p50/p65 heterodimer.

• Frances E. Chen, S J Kempiak, Dading Huang, Christopher B. Phelps, Gourisankar Ghosh
• Protein engineering
• 1999

NFkappaB plays an important role in mediating the gene expression of numerous cellular processes such as growth, development, the inflammatory response and virus proliferation. The p50/p65… (More)

Specific regulation of fos family transcription factors in thymocytes at two developmental checkpoints.

• Frances E. Chen, Danian Chen, Ellen V Rothenberg
• International immunology
• 1999

A central question in T cell development is what makes cortical thymocytes respond to stimulation in a qualitatively different way than any other thymocyte subset. Part of the answer is that AP-1… (More)

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