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OBJECTIVES To compare two sarcopenia definitions and examine the relationship between them and lower extremity function and other health related factors using data from the baseline examination of the Health Aging and Body Composition (Health ABC) Study. DESIGN Observational cohort study. SETTING Two U.S. communities in Memphis, Tennessee, and(More)
BACKGROUND The loss of muscle mass is considered to be a major determinant of strength loss in aging. However, large-scale longitudinal studies examining the association between the loss of mass and strength in older adults are lacking. METHODS Three-year changes in muscle mass and strength were determined in 1880 older adults in the Health, Aging and(More)
Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects(More)
CONTEXT Several studies have reported an association between the metabolic syndrome and cardiovascular disease. Despite an increasing awareness that cardiovascular risk factors increase risk of cognitive decline and dementia, there are few data on the metabolic syndrome and cognition. OBJECTIVE To determine if the metabolic syndrome is a risk factor for(More)
OBJECTIVES To compare two methods for classifying an individual as sarcopenic for predicting decline in physical function in the Health, Aging and Body Composition Study. DESIGN Observational cohort study with 5 years of follow-up. SETTING Communities in Memphis, Tennessee, and Pittsburgh, Pennsylvania. PARTICIPANTS Men and women aged 70 to 79(More)
OBJECTIVES To define clinically relevant cutpoints for usual gait speed and to investigate their predictive value for health-related events in older persons. DESIGN Prospective cohort study. SETTING Health, Aging and Body Composition Study. PARTICIPANTS Three thousand forty-seven well-functioning older persons (mean age 74.2). MEASUREMENTS Usual(More)
Adequate skeletal muscle strength is essential for physical functioning and low muscle strength is a predictor of physical limitations. Older adults with diabetes have a two- to threefold increased risk of physical disability. However, muscle strength has never been investigated with regard to diabetes in a population-based study. We evaluated grip and knee(More)
OBJECTIVE This study evaluated to what extent dual-energy X-ray absorptiometry (DXA) and two types of bioimpedance analysis (BIA) yield similar results for body fat mass (FM) in men and women with different levels of obesity and physical activity (PA). METHODS AND PROCEDURES The study population consisted of 37-81-year-old Finnish people (82 men and 86(More)
BACKGROUND Diabetes mellitus (DM) and related complications may increase clinical fracture risk in older adults. METHODS Our objectives were to determine if type 2 diabetes mellitus or impaired fasting glucose was associated with higher fracture rates in older adults and to evaluate how diabetic individuals with fractures differed from those without(More)
BACKGROUND It is unclear whether immediate dietary effects on blood glucose influence the risk of developing type 2 diabetes. OBJECTIVE The objective of this study was to examine whether the dietary glycemic index (GI) and glycemic load (GL) were associated with the risk of type 2 diabetes in older adults. DESIGN The Health, Aging, and Body Composition(More)