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HYPOTHESIS Studies were designed to ascertain the impact of chronic middle ear infection on the numerous ion and water channels, transporters, and tissue remodeling genes in the inner and middle ear.… (More)
HYPOTHESIS The inner ear (IE) endothelium is capable of responding to therapeutic steroids by altering the local expression of cytokine and ion homeostasis genes that impact inflammation and fluid… (More)
OBJECTIVE Otitis media is known to alter expression of cytokine and other genes in the mouse middle ear and inner ear. However, whole mouse genome studies of gene expression in otitis media have not… (More)
An overview of recent topics under investigation in our laboratory is presented. Topics include the cytokine and ion homeostasis gene response to steroids in the middle ear in a murine model of… (More)
Some experiments, often crucial for the comprehension of fundamental principles in physiology, neurophysiology, cardiology, endocrinology, or engineering domains can not be carried out by students… (More)
OBJECTIVES Glucocorticoids are given for sensorineural hearing loss, but little is known of their molecular impact on the inner ear. Furthermore, in spite of claims of improved hearing recovery with… (More)