Françoise Casanas-Roux

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Angiogenesis is likely to be involved in the pathogenesis of endometriosis. According to the transplantation theory, when the exfoliated endometrium is attached to the peritoneal layer, the establishment of a new blood supply is essential for the survival of the endometrial implant and development of endometriosis. From the known angiogenic factors,(More)
OBJECTIVE To evaluate the implantation of menstrual endometrium and the early stages of evolution of endometriotic lesions. DESIGN Experimental prospective study. SETTING An academic research environment. ANIMALS Ten nude mice. INTERVENTION(S) A minilaparotomy was performed to place fresh human menstrual endometrial samples in the peritoneal cavity.(More)
OBJECTIVE To compare histologic and ultrastructural characteristics of fresh and frozen-thawed human ovarian cortical tissue grafted into nude mice. DESIGN Experimental prospective study. SETTING An academic research environment. PATIENT(S) Ovarian biopsy specimens were obtained from 13 women undergoing laparoscopy for tubal ligation or infertility.(More)
A series of 231 cases of deep-infiltrating endometriosis of the rectovaginal septum is presented. Laparoscopic procedures with excision of deep fibrotic endometriotic nodules were performed in all cases. In three cases, the bowel lumen was entered. No other peri-operative complications were observed. Three cases of urinary retention were reported. The(More)
The management of large endometriomas was described in a series of 814 patients. Combined therapy using gonadotrophin-releasing hormone agonist (GnRHa) and carbon dioxide laser laparoscopy was proposed. Drainage and GnRHa for 12 weeks provoked a reduction of the endometrioma size up to 50% of the initial value. After vaporization of the internal wall, a(More)
OBJECTIVE To evaluate the role of GnRH agonist (GnRH-a) and/or drainage in the management of large endometriomas. DESIGN This prospective clinical study was conducted in a parallel and randomized design. SETTING Department of Gynecology, Cliniques Universitaires St. Luc, Brussels, Belgium. PATIENTS Eight infertile women with laparoscopically confirmed(More)
To evaluate the stromal vascularization of different appearances of peritoneal endometriosis, biopsies were taken from peritoneal areas with endometriosis in a series of 135 infertile women and classified as typical (black), red, or white lesions. The number of capillaries per mm2 of stroma, their mean surface area, and the ratio of capillaries/stroma(More)
OBJECTIVE Laparoscopic procedure with excision of deep fibrotic endometriotic nodules of the rectovaginal septum and histological study of the lesions. SETTING An academic teaching hospital. PARTICIPANTS A series of 500 women undergoing laparoscopy for pelvic pain or infertility. RESULTS Laparoscopic (n = 497) and laparotomic (n = 3) excision of(More)
OBJECTIVE To assess the proliferative activity of eutopic and ectopic endometrium throughout the menstrual cycle and its correlation to steroid receptor content. DESIGN The immunohistochemical use of Ki 67 was applied to investigate the proliferation index. A recently advanced stereographic computer technology was used to investigate steroid receptors. (More)
The cell proliferation-associated antigen Ki 67 and the immunohistochemical content of oestrogen receptors (ER), progesterone receptors AB (PRAB) and progesterone receptors B (PRB) were evaluated in leiomyomata and adjacent myometrium during the menstrual cycle and in leiomyomata under gonadotrophin-releasing hormone agonist (GnRHa) therapy. The(More)