Françoise Brion

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A traumatic injury of the anterior part of the corpus callosum led to a peculiar symptomatology associating motor conflicting behavior (diagnostic dyspraxia or voluntary ambivalence) and conflicting thoughts (emotional ambivalence) inducing a distressing feeling.
Clinical and anatomical report of a post traumatic amnestic syndrome (Korsakoff's syndrome), associating anterograde amnesia persisting for fifteen years, with temporal disorientation, false recognitions, initially intense transitory confabulation and secondarily bursts of confabulation, intact remote memory and persistence of old learnings. Death after(More)
BACKGROUND In the last decades, the provision of pharmaceutical care by community pharmacists has developed in OECD countries. These developments involved significant changes in professional practices and organization of primary care. In France, they have recently been encouraged by a new legal framework and favored by an increasing demand for health care(More)
OBJECTIVE The need for encouraging pediatric drug research is widely recognized. However, hospital-based clinical trials of drug treatments are extremely time-consuming, and delays in trial implementation are common. The objective of this qualitative study was to collect information on the perceptions and experience of health professionals involved in(More)
BACKGROUND The ethical, methodological, and technical aspects of pediatric research, often results in complications and delays in implementation. Our objective was to identify factors associated with the implementation duration of hospital-based pediatric studies. METHODS All hospital-based pediatric studies sponsored by AP-HP between 2002 and 2008 were(More)
Objective. The aim of this study was to investigate the use of "as needed" (pro re nata or prn) psychotropic medication in a child and adolescent psychiatric inpatient population. The study was carried out on the psychiatry ward of a paediatric teaching hospital in Paris, France. Methods. A prospective analysis of prn psychotropic drug prescriptions and(More)
Brain imaging showed extra-hippocampal temporal lesions in two patients with major disturbances of memory for academic knowledge including complete loss of professional knowledge and school learning especially regarding history, but sparing recent episodic memory in both cases and remote episodic memory in one of them. The antero-inferior and/or lateral(More)
Slices from rat cerebral cortex incubated in the presence of 2-deoxy[3H]glucose accumulate the sugar mainly in the form of its phosphorylated derivative. 2-Deoxy[3H]glucose uptake, measured under conditions of initial velocity, is stimulated by 50-100% in the presence of depolarising agents (KCl, veratridine) or the excitatory amino acids L- and(More)
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