Françoise Brion

Learn More
OBJECTIVE . To quantify the type and frequency of drug administration errors to pediatric in-patients and to identify associated factors. DESIGN Prospective direct-observation study of drug administration errors from April 2002 to March 2003. SETTING Four clinical units in a pediatric teaching hospital. STUDY PARTICIPANTS Twelve observers accompanied(More)
Objective. The aim of this study was to investigate the use of "as needed" (pro re nata or prn) psychotropic medication in a child and adolescent psychiatric inpatient population. The study was carried out on the psychiatry ward of a paediatric teaching hospital in Paris, France. Methods. A prospective analysis of prn psychotropic drug prescriptions and(More)
OBJECTIVE The aim of this study was to evaluate the relevance of the signals generated by a computerized drug-drug interaction detection system and to design a classification of overridden drug-drug interaction alerts. STUDY DESIGN Prospective study over two months. SETTING Five hundred and ten-bed university paediatric hospital. MAIN OUTCOME MEASURES(More)
Background Pediatric intensive care patients represent a population at high risk for drug-related problems. There are few studies that compare the activity of clinical pharmacists between countries. Objective To describe the drug-related problems identified and interventions by four pharmacists in a pediatric cardiac and intensive care unit. Setting Four(More)
Off-label or unlicensed medicine use is very common in paediatric practice, ranging from 11 to 80 %, and is one of the predisposing factors for adverse events (23–60 %). Medicine indications are the third leading reason for doctors to perform off-label prescriptions. The aim of our study was to determine the prevalence and nature of off-label and unlicensed(More)
Globotriaosylceramides (Gb(3)) are biological compounds implicated in Fabry disease, a lysosomal storage disease due to the deficient activity of alpha-D-galactosidase A, which results in an accumulation of Gb(3) in many organs. The naturally occurring samples are composed of mixtures of several molecular species differing by the structure of the alkyl(More)
Fabry disease (FD) is an X-linked inborn error of glycosphingolipid (GSL) metabolism, caused by a deficiency of the lysosomal alpha-galactosidase A, which results in high levels in lysosomes and biological fluids of globotriaosylceramide (Gb3) and digalactosylceramide (Ga2), also known as galabiosylceramide. We report here a detailed study of the molecular(More)
OBJECTIVE The need for encouraging pediatric drug research is widely recognized. However, hospital-based clinical trials of drug treatments are extremely time-consuming, and delays in trial implementation are common. The objective of this qualitative study was to collect information on the perceptions and experience of health professionals involved in(More)
To compare hospital pharmacy practice in France and Canada by identifying similarities and differences in the two institution’s pharmacy activities, resources, drug dispensing processes and responsibilities. Centre hospitalier universitaire Sainte-Justine (SJ), Montréal, Québec, Canada and Hôpital Robert Debré (RD), Paris, France, are two maternal-child(More)
In France, to practice as a pharmacist, one needs a "diplome d'état de Docteur en Pharmacie" This degree is awarded after 6 or 9 years of pharmacy studies, depending on the option chosen by the student. The degree is offered only at universities and is recognized in France as well as throughout the European Union. Each university in France is divided into(More)