François Van Laethem

Learn More
Signaling through the high affinity receptor for immunoglobulin E (Fc ⑀ RI) results in the coordinate activation of tyrosine kinases before calcium mobilization. Receptors capable of interfering with the signaling of antigen receptors, such as Fc ⑀ RI, recruit tyrosine and inositol phos-phatases that results in diminished calcium mobilization. Here, we show(More)
Thymic selection requires signaling by the protein tyrosine kinase Lck to generate T cells expressing αβ T cell antigen receptors (TCR). For reasons not understood, the thymus selects only αβTCR that are restricted by major histocompatibility complex (MHC)-encoded determinants. Here, we report that Lck proteins that were coreceptor associated promoted(More)
  • 1