François Van Laethem

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Signaling through the high affinity receptor for immunoglobulin E (Fc ⑀ RI) results in the coordinate activation of tyrosine kinases before calcium mobilization. Receptors capable of interfering with the signaling of antigen receptors, such as Fc ⑀ RI, recruit tyrosine and inositol phos-phatases that results in diminished calcium mobilization. Here, we show(More)
Thymic selection requires signaling by the protein tyrosine kinase Lck to generate T cells expressing αβ T cell antigen receptors (TCR). For reasons not understood, the thymus selects only αβTCR that are restricted by major histocompatibility complex (MHC)-encoded determinants. Here, we report that Lck proteins that were coreceptor associated promoted(More)
CTLA-4 proteins contribute to the suppressor function of regulatory T cells (Tregs), but the mechanism by which they do so remains incompletely understood. Introduction T cells are selected in the thymus to express TCRs reactive against foreign pathogens but tolerant to self-ligands. However, thymic selection is imperfect, so small numbers of potentially(More)
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