François R. Girardin

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OBJECTIVE To evaluate the cost-effectiveness of diagnostic strategies for coronary heart disease (CHD) derived from the CE-MARC study. DESIGN Cost-effectiveness analysis using a decision analytic model to compare eight strategies for the diagnosis of CHD. SETTING Secondary care out-patients (Cardiology Department). PATIENTS Patients referred to(More)
Detection of faults in roller element bearing is a topic widely discussed in the scientific field. Bearings diagnostics is usually performed by analyzing experimental signals, almost always vibration signals, measured during operation. A number of signal processing techniques have been proposed and applied to measured vibrations. The diagnostic(More)
Drug transporters are membrane proteins present in various tissues such as the lymphocytes, intestine, liver, kidney, testis, placenta, and central nervous system. These transporters play a significant role in drug absorption and distribution to organic systems, particularly if the organs are protected by blood-organ barriers, such as the blood-brain(More)
BACKGROUND In several countries medical prescription of diacetylmorphine is currently being evaluated as a treatment option for heavily dependent narcotic addicts. Because of damaged veins, many patients administer diacetylmorphine intramuscularly or orally. Therefore we characterized the pharmacokinetics of intramuscular and oral diacetylmorphine in the(More)
Liver kidney microsomal type 1 (LKM-1) antibodies have been shown to decrease the CYP2D6 activity in vitro and are present in a minority of patients with chronic hepatitis C infection. We investigated whether LKM-1 antibodies might reduce the CYP2D6 activity in vivo. All patients enrolled in the Swiss Hepatitis C Cohort Study and tested for LKM-1 antibodies(More)
BACKGROUND Drug manufacturers have developed "evergreening" strategies to compete with generic medication after patent termination. These include marketing of slightly modified follow-on drugs. We aimed to estimate the financial impact of these drugs on overall healthcare costs and also to examine the impact of listing these drugs in hospital restrictive(More)
IMPORTANCE Sudden cardiac death is a leading cause of mortality in psychiatric patients. Long QT (LQT) is common in this population and predisposes to Torsades-de-Pointes (TdP) and subsequent mortality. OBJECTIVE To estimate the cost-effectiveness of electrocardiographic screening to detect LQT in psychiatric inpatients. DESIGN, SETTING, AND(More)
Raynaud’s phenomenon (RP) is a common disease characterized by recurrent episodic vasospasms of the fingers and toes, typically triggered by exposure to cold and often associated with systemic diseases, endothelial damage, or drug exposure [1]. A 21-year-old woman started taking tegaserod (12 mg/day) in December. Two days later she experienced painful(More)
New direct-acting antivirals (DAA) against hepatitis C virus (HCV) have led to a therapeutic revolution in HCV management and virological cure rates approaching 100% while potentially avoiding significant complications of HCV (first cause of liver transplantation). We estimated the price of sustained virological response (SVR) depending on treatment(More)
A 28-year-old female patient, known for a primary antiphospholipid syndrome, presented in 1996 multiple documented thrombosis of the portal, mesenteric, left internal iliac and left gonadic veins. Since then, oral contraception (desogestrel) was stopped and oral anticoagulation (acenocoumarol) initiated. Regular ambulatory international normalized ratio(More)