François Le Dily

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The human genome is segmented into Topologically Associating Domains (TADs), but the role of this conserved organization during transient changes in gene expression is not known. Here we described the distribution of Progestin-induced chromatin modifications and changes in transcriptional activity over TADs in T47D breast cancer cells. Using ChIP-Seq, Hi-C(More)
We previously showed that COUP-TFI interacts with the Estrogen Receptor alpha (ERα) to recruit Extracellular signal Regulated Kinases (ERKs) in an Estradiol (E2)-independent manner, resulting in an enhancement of ERα transcriptional activity. However, the involvement of COUP-TFI in physiologically relevant functions of ERα, such as the mitogenic activity(More)
T47D_rep2 and b1913e6c1_51720e9cf were two Hi-C samples. They were born and processed at the same time, yet their fates were very different. The life of b1913e6c1_51720e9cf was simple and fruitful, while that of T47D_rep2 was full of accidents and sorrow. At the heart of these differences lies the fact that b1913e6c1_51720e9cf was born under a lab culture(More)
HiC­inspector is a toolkit for the analysis and visualization of data generated by high­throughput chromatin conformation capture (HiC). The analysis module comprises steps of data formatting, genome alignment, quality control and filtering, identification of genome­wide chromatin interactions, and statistics. The interactive browser enables visual(More)
AFFILIATIONS 1Gene Regulation, Stem Cells and Cancer Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona, 08003; Spain 2Universitat Pompeu Fabra (UPF), Barcelona, 08003; Spain 3Structural Genomics Group, CNAG-CRG, The Barcelona Institute of Science and Technology (BIST), Barcelona, 08003; Spain(More)
Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain Bioinformatics Unit, Biotechnology Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain Centre de Regulació Genòmica (CRG), Barcelona Institute for(More)
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