François Lauzier

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CONTEXT Between March and July 2009, the largest number of confirmed cases of 2009 influenza A(H1N1) infection occurred in North America. OBJECTIVE To describe characteristics, treatment, and outcomes of critically ill patients in Canada with 2009 influenza A(H1N1) infection. DESIGN, SETTING, AND PATIENTS A prospective observational study of 168(More)
BACKGROUND Severe traumatic brain injury often leads to death from withdrawal of life-sustaining therapy, although prognosis is difficult to determine. METHODS To evaluate variation in mortality following the withdrawal of life-sustaining therapy and hospital mortality in patients with critical illness and severe traumatic brain injury, we conducted a(More)
To compare the effects of arginine-vasopressin (AVP) and norepinephrine (NE) on hemodynamic variables, organ dysfunction, and adverse events in early hyperdynamic septic shock. Randomized, controlled, open-label trial. Twenty-three patients with early (12 h) hyperdynamic septic shock in two teaching hospitals. AVP (0.04–0.20 U min–1, n = 13) as a single(More)
OBJECTIVES To determine the ability and accuracy of the S-100β protein in predicting prognosis after a moderate or severe traumatic brain injury. DESIGN Systematic review and meta-analysis of randomised controlled trials and observational studies. DATA SOURCES Medline, Embase, Cochrane Central Register of Controlled Trials, BIOSIS (from their inception(More)
OBJECTIVES To assess the clinical outcomes, predictors, and prevalence of anterior pituitary disorders following traumatic brain injury. DATA SOURCES We searched Medline, Embase, Cochrane Registry, BIOSIS, and Trip Database up to February 2012 and consulted bibliographies of narrative reviews and selected articles. STUDY SELECTION We included cohort,(More)
INTRODUCTION Various strategies have been proposed for postoperative pain control. Among those, intravenous lidocaine infusion (IVLI) has gained in interest. However, its clinical benefit remains unclear. This systematic review is an evaluation of the analgesic efficacy and safety of IVLI during general anesthesia. METHODS A systematic search was(More)
OBJECTIVE To prospectively compare three methods of apnea testing for the confirmation of brain death. DESIGN Prospective, randomized, crossover study. SETTING Intensive care unit of a tertiary care university hospital. PATIENTS Twenty adult patients requiring apnea testing for confirmation of brain death. INTERVENTIONS Ten minute apnea testing was(More)
Injury to the alveolocapillary barrier characterizes ALI/ARDS; therefore determining levels of lung epithelium-specific small proteins in serum may help predict clinical outcomes. We examined whether serum Clara cell protein (CC-16) concentration is correlated with the outcome, mechanical ventilation duration, and incidence of nonpulmonary organ failure.(More)
OBJECTIVES Although guidelines for fresh frozen plasma (FFP) use have been published, many transfusions are considered inappropriate. Current guidelines suggest few circumstances in which FFP transfusion to critically ill patients is warranted. The objectives of this study were to evaluate the consistency of Canadian guidelines for FFP administration to(More)
BACKGROUND The clinical significance of elevated cardiac troponin (cTn) level in patients in the intensive care unit (ICU) is uncertain. We reviewed the frequency of cTn elevation and its association with mortality and length of ICU stay in these patients. METHODS Studies were identified using MEDLINE, EMBASE, and reference list review. We included(More)