François Huguenin

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Extracellular pH (pHo) and intracellular pH (pHi) of superficial fibres of the rat soleus muscle were measured in vitro using pH-sensitive glass micro-electrodes. The origin of the pH gradient existing between the bulk phase of extracellular solution and the surface of muscle fibres was investigated. The pHo decreased almost linearly over a distance of 285(More)
1. The membrane potential of isolated frog muscle fibres has been measured in absence and in presence of CO2, at constant external pH. 2. At a normal external Cl concentration, CO2 (PCO2 = 97 mmHg; pH = 7.0) applied for 10 min caused a highly variable depolarization, the average potential change being 8 mV after 5 min. The effect was reversible 3. In(More)
1. The short-term influence of catecholamines on surface pH (pHs) and intracellular pH (pHi) of superficial muscle fibres has been investigated in rat soleus in vitro using single-barrelled and double-barrelled glass micro-electrodes. pHs means the pH recorded at the surface of a muscle fibre. All measurments were performed in high-Ca2+ (10 mM) Ringer's(More)
The vertebral column, consisting of individual Junghann's movement segments (smallest functional units), can show functional impairment (malfunction) producing peripheral pain mostly without an organic cause. In the ENT area there are many syndromes caused by such malfunction, mostly in the upper cervical spine. Spondylogenous disorders can perhaps trigger(More)
The short-term effect of carbon dioxide on resting potential (Em), intracellular potassium activity (aiK) and intracellular pH (pHi) has been investigated in frog skeletal muscle. The external pH was kept constant in the range 6.8-7.6 by addition of HCO-3 in presence of CO2. Measurements were done in single or surface fibres of the semitendinosus muscle.(More)
1. The membrane potential of frog skeletal muscle was measured in various solutions, in the presence and in the absence of the CO2/HCO 3 − buffer. 2. The CO2/HCO 3 − buffer ( $$P_{CO_2 } = 38 - 593 mm Hg$$ ; [HCO 3 − ]=5–25 mM/l) generally induced a reversible depolarization. 3. In the presence of Cl−, there was a slowly developing but marked(More)
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