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  • Gerard Gradwohl, Andrée Diérich, Marianne Lemeur, François Guillemot
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2000 (First Publication: 15 February 2000)
  • In the mammalian pancreas, the endocrine cell types of the islets of Langerhans, including the alpha-, beta-, delta-, and pancreatic polypeptide cells as well as the exocrine cells, derive fromContinue Reading
  • François Guillemot, Li-Ching Lo, Jane E Johnson, Anna B. Auerbach, Alexandra L. Joyner
  • Medicine, Biology
  • Cell
  • 1993 (First Publication: 1 November 1993)
  • The mouse Mash-1 gene, like its Drosophila homologs of the achaete-scute complex (AS-C), encodes a transcription factor expressed in neural precursors. We created a null allele of this gene byContinue Reading
  • Toshiyuki Ohtsuka, Makiko Ishibashi, Gerard Gradwohl, Shigetada Nakanishi, François Guillemot, Ryoichiro Kageyama
  • Medicine, Biology
  • The EMBO journal
  • 1999 (First Publication: 15 April 1999)
  • While the transmembrane protein Notch plays an important role in various aspects of development, and diseases including tumors and neurological disorders, the intracellular pathway of mammalian NotchContinue Reading
  • Jun Hatakeyama, Yasumasa Bessho, +4 authors Ryoichiro Kageyama
  • Biology, Medicine
  • Development
  • 2004 (First Publication: 15 November 2004)
  • Radial glial cells derive from neuroepithelial cells, and both cell types are identified as neural stem cells. Neural stem cells are known to change their competency over time during development:Continue Reading