François Coenen

Learn More
The development of a stable influenza subunit vaccine in the dry state was investigated. The influence of various carbohydrates, buffer types and freezing rates on the integrity of haemagglutinin after freeze-thawing or freeze-drying was investigated with a range of analytical and immunological methods. The use of fast freezing, Hepes buffer and(More)
In this study 27 full scale production batches of influenza sub-unit vaccine were evaluated on their stability. The batches varied with respect to the strains they contained and regarding the presence of the preservative thiomersal in the solution. The stability study showed that haemagglutinin content was the most sensitive parameter. An increase in the(More)
As part of its waste matter prevention policy, the Dutch government has tried over the past few years to stimulate pollution prevention in firms by means of so-called stimulation and learning projects. To be able to determine the effectiveness of future policies, an extensive evaluation study was performed in 1994 on the pollution prevention projects which(More)
LA21-processes, on the basis of chapter 28 of Agenda, are under way in more than 4000 municipalities all over the world. A Local Agenda 21 can be characterised as a local action plan for the achievement of sustainable development, which has to be worked out through a broad consultative process between local authorities, citizens and relevant stakeholder(More)
The European Community has named five emergencies as being priorities. These five emergencies are: the cardiorespiratory arrest, the myocardial infarction, the severe polytrauma, the cerebral vascular accident and the severe acute dyspnoea. In this article three of them are discussed. Seen with the eyes of a generalist the severe polytrauma requires simple(More)
A 34-year-old renal transplant recipient woman was admitted for severe headache, hyperacusis and vomiting. Serum creatinine concentration was 2.09 mg/dl (glomeru-lar filtration rate 27/ml/min/1.73 m 2). Treatment combined tacrolimus 20 mg/day, mycophenolate 1,000 mg/day, and methylprednisolone 4 mg/day, but no anticoagulant or antihypertensive drug. She was(More)
Although this is an unfrequently used technique, the authors report their early experience concerning twenty-seven cases of carotid artery revascularization under cervical plexus anesthesia. They express their surgical judgement about the advantages and the limits of the simplest and most reliable way of cerebral monitoring during the surgical procedure,(More)
  • 1