Fr. Schneider

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Nanoscale spacing between the plasma membrane and the underlying cortical actin cytoskeleton profoundly modulates cellular morphology, mechanics, and function. Measuring this distance has been a key challenge in cell biology. Current methods for dissecting the nanoscale spacing either limit themselves to complex survey design using fixed samples or rely on(More)
The rate of reaction of some derivatives and peptides of cysteine and a number of imidazole-SH-compounds with 5,5′-Dithio-bis-(2-nitrobenzoic acid) (DTNB) as well as the dependence of the reaction rate upon pH were investigated; for several compounds an equation is given, by which the rate constants and half reaction times can be estimated for various pH(More)
Hydrogen peroxide and formaldehyde, both products of catabolism of “Natulan”, inhibit DNA polymerase as well as DNA dependent RNA polymerase, as shown in the cell-free system. Formaldehyde, furthermore, interferes with the synthesis of nucleoside triphosphates. N-hydroxymethyl compounds which may be obtained from the breakdown of “Natulan” act like(More)
Cytostatic active methylhydrazine derivatives split off formaldehyde after mild dehydrogenation with potassium hexacyanoferrate (III). It is suggested that the primary formedazomethines andN-hydroxymethylderivatives participate in cytostatic efficacy by their alkylating ability (aminomethylation). Formaldehyde alone and its condensation products with(More)
o-Acetylation of cyclo-his-ser and cyclo-histhr in acetic acid/acetanhydride proceeds via intermolecular, and in the case of 4-hydroxyethyl-imidazole via intramolecular, acyl transfer. The highest rate of acetylation is observed with 4-hydroxyethyl-imidazole, and the most effective catalyst in the case of intermolecular acyl transfer is imidazole;(More)
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