Frédérick Viens

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Radical reductions of halogenated precursors bearing a heterocycle exo (α) to the carbon-centered radical proceed with enhanced anti-selectivity, a phenomenon that we termed "exocyclic effect". New experimental data and DFT calculations at the BHandHLYP/TZVP level demonstrate that the origin of the exocyclic effect is linked to the strain energy required(More)
Exocyclic radical reductions were thoroughly investigated in the context of the synthesis of polysubstituted tetrahydropyrans, which are found in numerous macrolides. The radical precursors studied herein were generated by tandem cycloetherification and iodoetherification reactions or, alternatively, by semicyclic acetals substitutions. DFT calculations(More)
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