Frédéric Texier

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UNLABELLED Early identification of patients with severe (discriminant function > or = 32) alcoholic hepatitis (AH) not responding to corticosteroids is crucial. We generated a specific prognostic model (Lille model) to identify candidates early on for alternative therapies. Three hundred twenty patients with AH prospectively treated by corticosteroids were(More)
Ischemic cholangitis is a common clinical feature, which is frequently related to impairment of hepatic arterial blood flow. However, biliary injury associated with portal thrombosis has also been reported but its exact pathogenesis is still unknown. Some authors have hypothesized that compression by surrounding dilated veins plays a key role in biliary(More)
BACKGROUND/AIMS In severe alcoholic hepatitis (AH), 40% of patients will obtain no benefit from corticosteroids. Improvement in management of non-responders is warranted and only pentoxifylline can be considered an alternative. A two-step strategy was evaluated consisting of early withdrawal of corticosteroids and a switch to pentoxifylline for 28(More)
Non-invasive continuous positive airway pressure (CPAP) seems to decrease the need for intubation in patients with severe cardiogenic pulmonary oedema (CPO) in the intensive care unit. The goals of our study were to delineate indications for CPAP in the emergency department, and to confirm its usefulness in such a setting. We retrospectively assess the(More)
BACKGROUND/AIMS The benefit of amantadine combination therapy, either with interferon (IFN) alone (double therapy) or with ribavirin and IFN (triple therapy) is unknown. METHODS We analyzed the effect of amantadine on the end-of-treatment virological response and the sustained response using meta-analysis of 31 randomized controlled trials. RESULTS(More)
We report the case of a 65-Year-old man with advanced hepatocellular carcinoma related to alcoholic cirrhosis who was hospitalised for oliguric renal failure. Investigations showed a severe nephrotic syndrome related to paraneoplastic membranous glomerulonephritis. The patient's course was temporarily stabilized with loop diuretics and dialysis but the(More)
The authors report the results from the ultrasonographic exploration of the gallbladder performed on 1823 patients. They found morphologic variations and abnormalities in more than 33% of gallbladders, topographic ones in about 3.5% of observations and only 3 cases of real duplication of the gallbladder. Folds and septa may induce traps during echographic(More)