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Major surface protein 5 (Msp5) of Anaplasma marginale is highly conserved in the genus Anaplasma and the antigen used in a commercially available competitive enzyme-linked immunosorbent assay (cELISA) for serologic identification of cattle with anaplasmosis. This study analyzes the degrees of conservation of Msp5 among various isolates of Anaplasma(More)
P-glycoprotein (p-gp) is a transmembrane protein functioning as a drug-efflux pump in the intestinal epithelium. Human patients with inflammatory bowel disease (IBD) who fail to respond to treatment with steroids express high levels of p-gp in lamina propria lymphocytes. The purpose of this study was to investigate p-gp expression in duodenal biopsy samples(More)
OBJECTIVE To assess the relationship between body weight and gastrointestinal transit times measured by use of a wireless motility capsule (WMC) system in healthy dogs. ANIMALS 31 healthy adult dogs that weighed between 19.6 and 81.2 kg. PROCEDURES Food was withheld overnight. The following morning, a WMC was orally administered to each dog, and each(More)
OBJECTIVE To compare repeatability of measurements of gastrointestinal tract motility in healthy dogs obtained by use of a wireless motility capsule (WMC) and scintigraphy. ANIMALS 6 healthy adult dogs (mean +/- SD body weight, 21.5 +/- 1.8 kg). PROCEDURES A radiolabeled test meal was offered immediately after oral administration of a WMC. Serial static(More)
Absence of dystrophin, as found in Duchenne boys, mdx mice and HFMD cats, leads to destabilization of the sarcolemmal-associated protein complex. Gene and cell therapy strategies aim to restore the dystrophin-associated protein complex. In order to better understand the cellular events involved in such therapy in feline and human muscular dystrophy, we(More)
HYPOTHESIS Certain variables that are routinely measured during the diagnostic evaluation of dogs with chronic enteropathies will be predictive for outcome and a new clinical disease activity index incorporating these variables can be applied to predict outcome of disease. ANIMALS Seventy dogs were entered into a sequential treatment trial with(More)
Homeostasis in the intestinal microenvironment between the immune system and luminal antigens appears disturbed in chronic enteropathies. Pro-inflammatory cytokines likely play a role in the pathogenesis of intestinal inflammation. Several inflammatory and immunoregulatory genes have associated nuclear factor-kappaB (NF-kappaB) binding sites, which allow(More)
BACKGROUND Histopathology is widely used for the diagnosis of inflammatory bowel disease in dogs. Variations in lesions and unavailability of uniform grading systems limit the usefulness of histologic examination. HYPOTHESIS CD3 cell numbers in chronic enteropathies of dogs correlate with clinical activity of the disease and with severity of(More)
OBJECTIVE To assess postoperative surgical site infection (SSI) rate and to identify associated predictive factors. STUDY DESIGN Prospective clinical study. ANIMALS Dogs and cats that had surgery (1010 interventions) during 58 weeks from April 1999 to June 2000. METHODS Data sheets were completed by clinicians. Patients were controlled for clinical(More)
Acinetobacter baumannii, Enterococcus faecalis, Enterococcus faecium, and Staphylococcus intermedius isolates from infected surgical wounds and other types of infections in a veterinary teaching hospital were typed by pulsed field gel electrophoresis. A first cluster of infections with a multiresistant A. baumannii strain was observed in dogs and cats in(More)