Frédéric Neumann

Learn More
Recently we have demonstrated inhibition of masculine differentiation in male offspring of female rabbits actively immunised against T. After passage through the placenta the T-antibodies not only inhibit the entry of T into the fetal target cells but also protect it from metabolism. Thus, besides marked feminisation, 1000-fold elevated plasma T levels in(More)
Primary neuroendocrine carcinoma arises mainly in the gastrointestinal tract, lungs and pancreas, localization in the fallopian tube is exceptional with only one case being reported in literature. This second case concerns a 54-year-old patient, diagnosed at the Pierre-Zobda-Quitman hospital. Tumor histology revealed a poorly differentiated carcinoma with(More)
Mature female rabbits immunized with T-3-BSA developed highly specific antisera against T. Animals with the highest antibody titres revealed elevated plasma T-levels up to 2 000 ng/dl (normal: 15 ng/dl). Nevertheless, mating was successful and pregnancy uncomplicated. Immediately after normal delivery, the newborns were bled and fixed in Bouin's solution.(More)
16 female rabbits were actively immunized against testosterone (T). 9 of them conceived and gave birth to 89 neonates. In all neonatal plasma samples antibodies against T were detected. In the males the plasma T levels were elevated 1,000-fold. The testes of these animals were examined by means of morphometrical and biochemical methods. The results indicate(More)
The capacity of Leydig cells for regeneration was investigated in 12 patients with prostatic carcinoma, who underwent subcapsular orchidectomy, and in rats after testicular necrosis produced by cadmium chloride. In rats, reappearance of Leydig cells originating from the tunica albuginea could be demonstrated by histology. Testosterone concentrations(More)
The antiandrogen, cyproterone acetate (CPA), prevents development of prostatic hyperplasia, induced in castrated dogs by a 6 month-treatment with 5α-androstane-3α,l 7β-diol (A)alone or in combination with 17β-oestradiol (E 2). The immunoperoxidase technique was used to study functional cell types in the pars distalis of the pituitary gland and to detect(More)
Pregnant guinea pigs were treated with cyproterone acetate from the 15th to the 40th day p.c. The dosage was 50, 75 and 100 mg/kg/day. On the 46th day p.c. the internal and external genitalia of untreated female and male foetuses and of male foetuses from treated mothers were prepared and histologically examined. Some fetuses, whose mothers had been treated(More)
  • 1