Frédéric Mille

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OBJECTIVE Available commercial drugs in France are often unsuitable for children. The aim of this study was, for every medicinal form orally or parenterally administered, to identify and to quantify difficulties met by the nurses administering drugs to paediatric inpatients and to propose solutions to main identified problems. MATERIAL AND METHOD The(More)
Quadriceps tendon avulsions are typically treated by reattaching the tendon through bone tunnels, with or without tendon or hardware augmentation. The operated knee joint can be moved right away; however, tendon grafting or tension banding will be required to protect the repair, and the hardware must be removed later on. The goal of this study was to(More)
OBJECTIVE The aim of this study was to evaluate the relevance of the signals generated by a computerized drug-drug interaction detection system and to design a classification of overridden drug-drug interaction alerts. STUDY DESIGN Prospective study over two months. SETTING Five hundred and ten-bed university paediatric hospital. MAIN OUTCOME MEASURES(More)
We report the first case of a massive accidental overdose of nevirapine in a 1-week newborn, due to confusion between nevirapine (Viramune) and nelfinavir (Viracept). The drug was eliminated spontaneously and quickly. We only observed mild neutropenia and hyperlactatemia, which regressed on its own without any clinical complication. Despite the good(More)
OBJECTIVES The effectiveness of computerized clinical decision support systems (CDSS) depends on the quality of the knowledge they refer to. In this article, we are interested in the acquisition, modeling and representation of the knowledge embedded in the "national reference framework of drug-drug interaction" published by the French Health Products Safety(More)
OBJECTIVES Surgical antimicrobial prophylaxis is used to decrease postoperative wound infection. We assessed the compliance to surgical antimicrobial prophylaxis guidelines in our hospital and the impact of an information program. PATIENTS AND METHODS Observational study of clean or clean contamined surgery, during two 3-week periods, separated by a(More)
A 39-year-old patient was admitted to the emergency department for acute abdominal pain. Physical examination showed a peritoneal syndrome. However, CT-scan, Doppler and blood analysis were unremarkable. As the patient had a history of auto-medication with benzodiazepines at high doses, a withdrawal syndrome was considered. An intravenous administration of(More)
OBJECTIVE The objective of this study was to analyze in a pediatric hospital the use of expensive drugs as part of the new activity-based system (T2A) of funding for French public hospitals. We identified and analyzed the therapeutic use of these drugs in indications not included in the expert recommendations issued to accompany this change, with the goal(More)
OBJECTIVES To compare three techniques of brachial plexus blockade for emergency surgery of the upper limb. STUDY DESIGN Prospective, randomised study. PATIENTS One hundred eleven patients admitted to an emergency surgical service, randomly assigned to three groups. METHODS The patients were given 2% lidocaine with epinephrine 20 mL and 0.5%(More)
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