Frédéric Lévesque

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ATP diphosphohydrolase (ATPDase) or apyrase (EC 3.6.1.5), an enzyme that hydrolyses the gamma and beta phosphate residues of triphospho- and diphosphonucleosides, has been purified from the bovine aorta media. A particulate fraction was isolated by differential, and sucrose cushion centrifugations, producing a 33-fold enrichment in ADPase activity.(More)
The motor deficits induced by red nucleus lesions have been well documented but so far based upon approaches destroying both cells and fibres of passage. In the present study we used kaïnic lesions, which are known to spare, at least partially, the fibres of passage in order to re-investigate the motor deficit induced by rubral lesion. Five cats were fully(More)
Laterality in paw use was investigated over a period of 6 years in 44 domestic cats trained to perform a reaching movement toward a moving spot of light. Both paw preference and paw performance were recorded. At a 50 percent criterion, no significant paw preference was found at the level of the group. When a 90 percent criterion was considered, 23 subjects(More)
OBJECTIVES Seasonal affective disorder (SAD) is characterized by a mood lowering in autumn and/or winter followed by spontaneous remission in spring or summer. Bright light (BL) is recognized as the treatment of choice for individuals affected with this disease. It was speculated that BL acts on photosensitive retinal ganglion cells, particularly sensitive(More)
The role of the ventrolateral thalamic nucleus (VL) has been analyzed in the phase of motor recovery that takes place when the execution of a previously learned movement has been perturbed by damage to another brain area. Cats were trained to perform a reaching movement toward a moving target-spot; they underwent bilateral brain lesions after performance(More)
Two ATP diphosphohydrolase (ATPDase) isoforms have been purified from the bovine heart ventricle. The purification procedure includes the following steps: differential centrifugation, sucrose cushion centrifugation, solubilization with Triton X-100, DEAE agarose ion exchange, and Affi-Gel blue-Sepharose and concanavalin A (con A)-Sepharose chromatographies.(More)
Detailed in vivo and in vitro studies of glucose and insulin metabolism in Friedreich's ataxia patients and unaffected family members have further defined the extent of the abnormalities in carbohydrate metabolism. The high incidence of glucose intolerance and a hyperinsulinemic response to a glucose challenge in a high percentage of Friedreich's ataxia(More)
Impairments in reaching toward stationary and moving targets were studied in cats after restricted or extensive removal of visual cortical areas (areas 17, 18 and 19 and lateral suprasylvian visual areas). Regardless of the extent of the cortical lesion, cats were at first unable to localise and reach for a stationary target whereas they were soon able to(More)
In order to test the hypothesis that visual information reaching the cerebellum through the pontine nuclei is involved in the control of visually guided movements, the effects of bilateral kainic acid pontine lesions have been analysed in cats performing a reaching movement towards a spot of light that was either stationary or moving. In 4 cats, the lesion(More)