Frédéric François

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In order to characterize the estrogenic activity of chemicals, we established complementary in vitro recombinant receptor-reporter gene assays in stably transfected MCF-7 and HeLa cells. MCF-7 cells which express the endogenous estrogen receptor alpha (ER alpha) were stably transfected with only an estrogen-regulated luciferase gene. These cells enable the(More)
Traceability is an important aspect of software development that is often required by various professional standards and government agencies. Yet current industrial approaches do not typically address end-to-end traceability. Moreover, many industry projects become entangled in process overhead and fail to derive much benefit from current traceability(More)
Programmed cell death, or apoptosis, occurs asynchronously in neuronal cells. To overcome this asynchrony, rat pheochromocytoma (PC12) cells were separated at different stages of apoptosis on the basis of cell density. Live cells that exhibited no apoptotic features floated to the top of density gradients. The most dense cells showed extensive loss of(More)
Programmed cell death, or apoptosis, is a tightly regulated process mediated by selective cleavage of proteins by caspases, resulting in ordered destruction of the cell. In addition to structural proteins, proteins that mediate anti-apoptotic signal transduction are also substrates; their destruction eliminates potential futile attempts to escape execution.(More)
Backbone network energy efficiency has recently become a primary concern for Internet Service Providers and regulators. The common solutions for energy conservation in such an environment include sleep mode reconfigurations and rate adaptation at network devices when the traffic volume is low. It has been observed that many ISP networks exhibit regular(More)
The energy consumption of backbone networks has become a primary concern for network operators and regulators due to the pervasive deployment of wired backbone networks to meet the requirements of bandwidth-hungry applications. While traditional optimization of IGP link weights has been used in IP based load-balancing operations, in this paper we introduce(More)
We present and experimentally assess in an international testbed an ABNO-based network orchestrator for end-to-end multi-layer (OPS and Flexi-grid OCS) and multi-domain provisioning across heterogeneous control domains (SDN/OpenFlow and GMPLS/Stateful PCE) employing dynamic domain abstraction based on virtual node aggregation. Introduction When a physical(More)
Neuronal apoptotic execution uses a cytochrome c-dependent caspase activation mechanism that is conserved in other cell types. Phosphatidylinositol 3-kinase and its downstream effector, Akt/protein kinase B, appear to control this mechanism and govern the life/death decision. We have developed a cell-free system using cytosol from human neuroblastoma (SY5Y)(More)
Signaling storms in mobile networks, which congest the control plane, are becoming more frequent and severe because misbehaving applications can nowadays spread more rapidly due to the popularity of application marketplaces for smartphones. While previous work on signaling storms consider the processing overhead in the network and energy consumption of the(More)
Energy consumption in ISP backbone networks has been rapidly increasing with the advent of increasingly bandwidth-hungry applications. Network resource optimization through sleeping reconfiguration and rate adaptation has been proposed for reducing energy consumption when the traffic demands are at their low levels. It has been observed that many(More)