Frédéric DuBru

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Multidrug resistance (MDR) is frequently associated with decreased cellular drug accumulation resulting from enhanced drug efflux. This is correlated with the presence of a membrane protein, the P-glycoprotein, which pumps a wide variety of drugs out of cells, reducing their intracellular concentration and thus their toxicity. The influx and efflux of drugs(More)
Requirements Engineering is now widely recognised as a key issue in the design and implementation of information systems. Recent research trends plead for the use of formal (i.e. mathematical/logical) languages at this stage of analysis in order to cope with the classical difficulties arisen from the interactions with customers. In this paper, we introduce(More)
The multidrug resistance protein (MRP) has been shown to mediate ATP-dependent efflux of anticancer agents of diverse structure, such as daunorubicin (DNR), vincristine and etoposide. Thus, this protein does confer a multidrug resistant phenotype to cancer cells, similar to P-glycoprotein (Pgp). The substrate specificity of both transporter proteins is(More)
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