Frédéric Boschet

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An analytical method for the determination of benazepril and its active metabolite, benazeprilat, in human plasma by capillary gas chromatography-mass-selective detection, with their respective labelled internal standard, was developed and validated according to international regulatory requirements. After addition of the internal standards, the compounds(More)
A persistent perfluoroalkyl radical (PPFR), perfluoro-3-ethyl-2,4-dimethyl-3-pentyl, is shown to be a good source of •CF(3) radicals and a useful radical capable of initiating the polymerization of vinylidene fluoride (VDF). NMR characterizations of the resulting PVDF homopolymers showed that polymerization of VDF was exclusively initiated by •CF(3) (More)
Fluorinated copolymers bearing ammonium groups were prepared by radical copolymerization of fluorinated olefins (chlorotrifluoroethylene, hexafluoropropylene) with different vinyl ethers (2-chloroethyl, cyclohexyl, n-butyl, and ethyl vinyl ethers) followed by the cationization of these copolymers with trimethylamine. Copolymers were obtained in high yield(More)
The synthesis of original co-telomers based on 3,3,3-trifluoropropene (TFP) and vinylidene fluoride (VDF) with a general formula: RF-[CH2-CF2]n-[CH2-CH(CF3)]m-I (where n=1-63, m=2-640, and RF=(CF3)2CF) was achieved by sequential and random cotelomerizations in the presence of RFI. The radical cotelomerizations were initiated by thermal decomposition of(More)
The synthesis of original co-telomers based on 3,3,3-trifluoropropene (TFP) and vinylidene fluoride (VDF) with a general formula: RF-[CH2-CF2]n-[CH2-CH(CF3)]m-I (where n=1-63, m=2-640, and RF=(CF3)2CF) was achieved by sequential and random cotelomerizations in the presence of RFI. The radical cotelomerizations were initiated by thermal decomposition of(More)
The percutaneous absorption of diclofenac was studied in ten healthy volunteers treated with Emulgel containing 1.16% diclofenac diethylammonium for 8 d as follows: a single application of 5 g Emulgel on days 1 and 8, and two applications d-1 on days 2-7. Plasma concentration profiles of unchanged diclofenac and urinary concentrations of total diclofenac(More)
The radical copolymerization of two different methacrylate monomers, 2,2,2trifluoroethyl methacrylate (TFEMA) and tert-butyl -trifluoromethacrylate (TBTFMA) in solution was investigated. The resulting statistic poly(TFEMA-co-TBTFMA) copolymers were characterized by NMR spectroscopy to assess their compositions. The kinetics of copolymerization enabled one(More)
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