Frédéric Alexandre

Learn More
Alzheimer's disease (AD) is an age-related neurodegenerative disorder associated with progressive memory loss, severe dementia, and hallmark neuropathological markers, such as deposition of amyloid-β (Aβ) peptides in senile plaques and accumulation of hyperphosphorylated tau proteins in neurofibrillary tangles. Recent evidence obtained from transgenic mouse(More)
Modeling visual perception of motion by connectionist networks offers various areas of research for the development of real-time models of dynamic perception-action. In this paper we present the bases of a bio-inspired connectionist approach that is part of our development of neural networks applied to autonomous robotics. Our model of visual perception of(More)
We ask the question whether the coding of categorical versus coordinate spatial relations depends on different neural networks showing hemispheric specialization or whether there is continuity between these two coding types. The 'continuous spatial coding' hypothesis would mean that the two coding types rely essentially on the same neural network consisting(More)
Visual analysis of the physiological signals recorded at sleep time constitutes a heavy task for the clinician. In fact data quantity to be analyzed, generally corresponding to eight hours of recordings studied per 30s epochs, as well as the complexity of this analysis require a significant time. The objective of our work is to propose a tool for automatic(More)
The visual exploration of a scene involves the interplay of several competing processes (for example to select the next saccade or to keep fixation) and the integration of bottom-up (e.g. contrast) and top-down information (the target of a visual search task). Identifying the neural mechanisms involved in these processes and in the integration of these(More)
Recent advances in neuroscience give us a better view of the inner structure of the amygdala, of its relations with other regions in the Medial Temporal Lobe (MTL) and of the prominent role of neuromodulation. They have particularly shed light on two kinds of neurons in the basal nucleus of the amygdala, the so-called fear neurons and extinction neurons.(More)