Frédéric Alexandre

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Alzheimer's disease (AD) is an age-related neurodegenerative disorder associated with progressive memory loss, severe dementia, and hallmark neuropathological markers, such as deposition of amyloid-β (Aβ) peptides in senile plaques and accumulation of hyperphosphorylated tau proteins in neurofibrillary tangles. Recent evidence obtained from transgenic mouse(More)
The visual exploration of a scene involves the interplay of several competing processes (for example to select the next saccade or to keep fixation) and the integration of bottom-up (e.g. contrast) and top-down information (the target of a visual search task). Identifying the neural mechanisms involved in these processes and in the integration of these(More)
We ask the question whether the coding of categorical versus coordinate spatial relations depends on different neural networks showing hemispheric specialization or whether there is continuity between these two coding types. The 'continuous spatial coding' hypothesis would mean that the two coding types rely essentially on the same neural network consisting(More)
The ultimate|if implicit|goal of artiicial intelligence (AI) research is to model the full range of human cognitive capabilities. Symbolic AI and connectionism, the major AI paradigms, have each tried|and failed|to attain this goal. In the meantime, the idea has gained ground that this goal might still be within reach if we could harness the respective(More)
Since the mid-1980s, researchers have been pursuing the goal of neurosymbolic integration, i.e., the construction of systems capable of both symbolic and neural processing. We distinguish two major avenues toward this goal: the uniied and the hybrid approaches. Whereas the uniied approach claims that full symbol processing functionalities can be achieved(More)