Fotios Papadimitrakopoulos

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Devices for continuous glucose monitoring (CGM) are currently a major focus of research in the area of diabetes management. It is envisioned that such devices will have the ability to alert a diabetes patient (or the parent or medical care giver of a diabetes patient) of impending hypoglycemic/hyperglycemic events and thereby enable the patient to avoid(More)
The development of zero-order release systems capable of delivering drug(s) over extended periods of time is deemed necessary for a variety of biomedical applications. We hereby describe a simple, yet versatile, delivery platform based on physically cross-linked poly(vinyl alcohol) (PVA) microgels (cross-linked via repetitive freeze/thaw cycling) containing(More)
Attaining high photoluminescence quantum yields for single-walled carbon nanotubes (SWNTs) in order to broaden their optoelectronics and sensing applications has been a challenging task. Among various nonradiative pathways, sidewall chemisorption of oxygen provides a known defect for exciton quenching through nanotube hole doping. We found that an aliphatic(More)
This work proposes a potentiostat circuit for multiple implantable sensor applications. Implantable sensors play a vital role in continuous in situ monitoring of biological phenomena in a real-time health care monitoring system. In the proposed work a three-electrode based electrochemical sensing system has been employed. In this system a fixed potential(More)
OBJECTIVE Development of electrochemical sensors for continuous glucose monitoring is currently hindered by a variety of problems associated with low selectivity, low sensitivity, narrow linearities, delayed response times, hysteresis, biofouling, and tissue inflammation. We present an optimized sensor architecture based on layer stratification, which(More)
Ab initio computational studies were performed for CdSe nanocrystals over a wide range of sizes and topologies. Substantial relaxations and coordination of surface atoms were found to play a crucial role in determining the nanocrystal stability and optical properties. While optimally ͑threefold͒ coordinated surface atoms resulted in stable closed-shell(More)
Operating lifetime is the main problem that complicates the use of polymeric light-emitting diodes (LEDs). A class of electron transport (ET) polymers [poly(aryl acrylate) and poly(aryl ether)s] is reported in which moieties with high electron affinities are covalently attached to stable polymer backbones. Devices based on poly(p-phenylenevinylene) (PPV)(More)
Integrated microfluidic devices with nanosized array electrodes and microfiltration capabilities can greatly increase sensitivity and enhance automation in immunoassay devices. In this contribution, we utilize the edge-patterning method of thin aluminum (Al) films in order to form nano- to micron-sized gaps. Evaporation of high work-function metals (i.e.,(More)
Unlike non-invasive and minimally invasive continuous monitoring of glucose (CGM) devices, invasive devices require less rigorous calibration and exhibit smaller subject-to-subject variability. Biorasis, Inc. and the University of Connecticut are developing a totally implantable CGM device. Glucowizzard™ is engineered at the smallest possible(More)
This paper presents the design and fabrication of a highly-miniaturized system for continuous glucose monitoring which holds great promise for patients inflicted with diabetes mellitus. To achieve the realization of a truly implantable system, a variety of issues such as robust electrochemical sensor design, miniaturization of the electronic components and(More)