Fotios Papadimitrakopoulos

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The development of zero-order release systems capable of delivering drug(s) over extended periods of time is deemed necessary for a variety of biomedical applications. We hereby describe a simple, yet versatile, delivery platform based on physically cross-linked poly(vinyl alcohol) (PVA) microgels (cross-linked via repetitive freeze/thaw cycling) containing(More)
Integrated microfluidic devices with nanosized array electrodes and microfiltration capabilities can greatly increase sensitivity and enhance automation in immunoassay devices. In this contribution, we utilize the edge-patterning method of thin aluminum (Al) films in order to form nano- to micron-sized gaps. Evaporation of high work-function metals (i.e.,(More)
The performance of implantable electrochemical glucose sensors is highly dependent on the flux-limiting (glucose, H(2)O(2), O(2)) properties of their outer membranes. A careful understanding of the diffusion profiles of the participating species throughout the sensor architecture (enzyme and membrane layer) plays a crucial role in designing a robust sensor(More)
The role of oxygen in directing the low temperature (125 degrees C), redox-assisted, unidimensional and unidirectional growth of CdSe nanocrystals (NCs) was investigated. In the presence of oxygen, CdSe quantum dots grow selectively along their c axis with little to no change in their width. Reduction of oxygen in the growth medium results in(More)
Prostate Specific Antigen (PSA) is a major biomarker used clinically in the detection of p r o s t a t e c a n c e r. C u r r e n t c o m m e r c i a l immunoassays for detection of this biomarker rely on spectroscopic absorbance and electro-chemiluminescence which are able to detect as low as 0.03 ng/mL of PSA within ȝ/ RI serum. In this paper a no vel amp(More)
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