Learn More
Chromosomes from successive passages of a Chinese ham ster cell strain (WCHE/5) that spontaneously progressed from a euploid primary cell culture to a heteroploid tumorigenic cell line were isolated and analyzed by Giemsa banding and high-reso lution flow karyotype analysis. The frequency and identification of aneuploid and marker chromosomes were(More)
Estimates of cancer risks posed to space-flight crews by exposure to high atomic number, high-energy (HZE) ions are subject to considerable uncertainty because epidemiological data do not exist for human populations exposed to similar radiation qualities. We assessed the carcinogenic effects of 300 MeV/n 28Si or 600 MeV/n 56Fe ions in a mouse model for(More)
Chromosomal rearrangements are a source of structural variation within the genome that figure prominently in human disease, where the importance of translocations and deletions is well recognized. In principle, inversions—reversals in the orientation of DNA sequences within a chromosome—should have similar detrimental potential. However, the study of(More)
Exposure to sparsely ionising gamma- or X-ray irradiation is known to increase the risk of leukaemia in humans. However, heavy ion radiotherapy and extended space exploration will expose humans to densely ionising high linear energy transfer (LET) radiation for which there is currently no understanding of leukaemia risk. Murine models have implicated(More)
  • F. Andrew Ray
  • 2008
TnT: T antigen and telomerase, an explosive route to cancer * Sir, Early this century when Hanahan and Weinberg enumerated the six phenotypes that they defined as the 'Hallmarks of Cancer', they segregated genomic instability as 'an enabling characteristic' rather than defining it as a hallmark. Reading more carefully, we learn that they have set genomic(More)
Three distinct types of opioid receptors are found in the nervous system: mu, kappa, and delta. Classic clinically used opioid analgesics act primarily as agonists or partial agonists at mu receptors. Heroin or illicit prescription opioids also act primarily as mu opioid receptor (MOP-r) agonists. Compounds in this class include the natural opiates (drugs(More)
  • 1