Floris P de Lange

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To plan a reaching movement, the brain must integrate information about the location of the target with information about the limb selected for the reach. Here, we applied rapid event-related 3-T fMRI to investigate this process in human subjects (n = 16) preparing a reach following two successive visual instruction cues. One cue instructed which arm to(More)
It is generally accepted that interactions between parietal and frontal cortices subserve the visuomotor processing for eye and hand movements. Here, we used a sequential-instruction paradigm in 3-T functional MRI to test the processing of effector and spatial signals, as well as their interaction, as a movement is composed and executed in different stages.(More)
Twelve right-handed men performed two mental rotation tasks and two control tasks while whole-head functional magnetic resonance imaging was applied. Mental rotation tasks implied the comparison of different sorts of stimulus pairs, viz. pictures of hands and pictures of tools, which were either identical or mirror images and which were rotated in the plane(More)
Repetition suppression, the phenomenon that the second presentation of a stimulus attenuates neural activity, is typically viewed as an automatic consequence of repeated stimulus presentation. However, a recent neuroimaging study has suggested that repetition suppression may be driven by top-down expectations. Here we examined whether and when repetition(More)
Predictive coding models suggest that predicted sensory signals are attenuated (silencing of prediction error). These models, though influential, are challenged by the fact that prediction sometimes seems to enhance rather than reduce sensory signals, as in the case of attentional cueing experiments. One possible explanation is that in these experiments,(More)
Repetition suppression in fMRI studies is generally thought to underlie behavioural facilitation effects (i.e., priming) and it is often used to identify the neuronal representations associated with a stimulus. However, this pays little heed to the large number of repetition enhancement effects observed under similar conditions. In this review, we identify(More)
How do expectations about the identity of a forthcoming visual stimulus influence the neural mechanisms of perceptual decision making in the human brain? Previous investigations into this issue have mostly involved changing the subjects' attentional focus or the behavioral relevance of certain targets but rarely manipulated subjects' prior expectation about(More)
A recent study found that, across individuals, gray matter volume in the frontal polar region was correlated with visual metacognition capacity (i.e., how well one's confidence ratings distinguish between correct and incorrect judgments). A question arises as to whether the putative metacognitive mechanisms in this region are also used in other(More)
For social beings like humans, detecting one's own and others' errors is essential for efficient goal-directed behavior. Although one's own errors are always negative events, errors from other persons may be negative or positive depending on the social context. We used neuroimaging to disentangle brain activations related to error and reward processing, by(More)
In neurodegenerative disorders, neural damage can trigger compensatory mechanisms that minimize behavioural impairments. Here, we aimed at characterizing cerebral compensation during motor imagery in Parkinson's disease (PD), while controlling for altered motor execution and sensory feedback. We used a within-patient design to compare the most and least(More)