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Drug release from collagen matrices is in most cases governed by diffusion from swollen matrices but also enzymatic matrix degradation or hydrophobic drug/collagen interactions may contribute. To reduce water uptake and to prolong the release, insoluble collagen matrices have been chemically or dehydrothermally crosslinked. Assuming Fickian diffusion a(More)
A drug delivery system, named minirod, containing insoluble non-cross-linked collagen was prepared to investigate the release of model drug compounds. To characterise the complete drug release process properly, a mathematical model was developed. Previously, a mathematical model describing water penetration, matrix swelling and drug release by diffusion(More)
In this paper we analyze an Euler implicit-mixed finite element scheme for a porous media solute transport model. The transporting flux is not assumed given, but obtained by solving numerically the Richards equation, a model for sub-surface fluid flow. We prove the convergence of the scheme by estimating the error in terms of the discretization parameters.(More)
In this paper we analyze the convergence of a numerical scheme for a class of degenerate parabolic problems. Such problems are often used to model reactions in porous media, and involve a nonlinear, possibly vanishing diffusion. The scheme considered here involves the Kirchhoff transformation coupled with the regularization of the nonlinearity, and is based(More)