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The Na(+)/H(+) exchanger isoform 1 (NHE1) is a ubiquitously expressed transporter fulfilling a variety of cell physiological tasks. By importing Na(+) and exporting H(+), NHE1 contributes to… (More)
Detachment of cells from the primary tumour precedes metastatic progression by facilitating cell release into the tissue. Solid tumours exhibit altered pH homeostasis with extracellular… (More)
Many tumor cells are characterized by an increased net acid production. They extrude the excess protons mainly through the Na(+) /H(+) -exchanger NHE1. An increased NHE1 activity elevates the… (More)
Cell motility is an essential feature of life. It is essential for reproduction, propagation, embryonic development, and healing processes such as wound closure and a successful immune defense. If… (More)