Florian Schuch

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OBJECTIVE To prospectively analyse the risk for disease relapses in patients with rheumatoid arthritis (RA) in sustained remission, either continuing, tapering or stopping disease-modifying antirheumatic drugs (DMARDs) in a prospective randomised controlled trial. METHODS Reduction of Therapy in patients with Rheumatoid arthritis in Ongoing remission is a(More)
OBJECTIVES To investigate the occurrence and risk factors for infections in RA patients treated with tocilizumab. METHODS A cohort of all RA patients (n = 112) starting tocilizumab therapy between October 2008 and March 2010 in Northern Bavaria was screened for infections. Mild/moderate and severe infections were recorded. Multivariate logistic regression(More)
OBJECTIVE To analyse the role of multibiomarker disease activity (MBDA) score in predicting disease relapses in patients with rheumatoid arthritis (RA) in sustained remission who tapered disease modifying antirheumatic drug (DMARD) therapy in RETRO, a prospective randomised controlled trial. METHODS MBDA scores (scale 1-100) were determined based on 12(More)
OBJECTIVES Recent findings suggest that autoimmune disorders predispose to a diminished capacity to taste and smell. This has been shown for patients with systemic lupus erythematosus as well as for patients with rheumatoid arthritis (RA). Granulomatosis with polyangiitis (GPA), with its particular manifestations in the upper respiratory tract, may(More)
OBJECTIVE To investigate whether MHC class II expression on myeloid cells of patients with treatment-naive early rheumatoid arthritis (RA) correlates with disease progression. METHODS Monocytes were isolated by negative selection from the peripheral blood of 15 patients with early RA (disease duration < or =12 months), differentiated to macrophages and(More)
Radiosynovectomy or radiosynoviorthesis (RSO), the intra-articular injection of beta-emitting radionuclides (e.g. colloidal preparations of 90-Yttrium, 186-Rhenium or 169-Erbium), is an approved, reliable and easily performed therapy for the treatment of chronic synovitis without harmful side effects. The best clinical results have been obtained in patients(More)
Das Management von Patienten mit Spondyloarthritiden (SpA) hat in den letzten Jahren einen Paradigmenwechsel erlebt. Dies gilt sowohl für die Behandlung der axialen als auch der peripheren Manifestationen. Basierend auf der Treat-to-target(T2T)-Strategie sind für die SpA nun ebenfalls internationale T2T-Empfehlungen publiziert worden, die neben 15(More)
PURPOSE To use the Monte Carlo code PENELOPE to study attenuation and tissue equivalence properties of a-Al2O3:C for OSL dosimetry. METHODS Mass attenuation coefficients of α-Al2O3 and α-Al2O3:C with carbon percent weight concentrations from 1% to 150% were simulated with PENELOPE Monte Carlo code and compared to mass attenuation coefficients from soft(More)
In einer gemeinsamen Initiative des Vorstands der Deutschen Gesellschaft für Rheumatologie (DGRh) und des Verbands rheumatologischer Akutkliniken (VRA) wurden die kürzlich vom European Musculoskeletal Conditions Surveillance and Information Network (eumusc.net) vorgeschlagenen und von der European League Against Rheumatism (EULAR) unterstützten europäischen(More)
OBJECTIVE To perform a detailed analysis of the autoantibody response against post-translationally modified proteins in patients with rheumatoid arthritis (RA) in sustained remission and to explore whether its composition influences the risk for disease relapse when tapering disease modifying antirheumatic drug (DMARD) therapy. METHODS Immune responses(More)